Immunotherapy
Immunotherapy is the treatment of disease by inducing, enhancing or suppressing an immune response. Activation immunotherapies induce or amplify an immune response and are used in vaccines and as cancer immunotherapies. Suppression immunotherapies reduce or suppress an immune response and are used to prevent graft rejection and treat autoimmunity and allergy.
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CD8+ T cells pass the acid test
Persistent mutations render cancer cells susceptible to immunotherapy
Off-the-shelf CAR T cells for multiple myelomaLatest Research and Reviews
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Research
| Open Access
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Nature Communications 14, 86 -
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TET2 guards against unchecked BATF3-induced CAR T cell expansion
Locally sourced: site-specific immune barriers to metastasis
Synapse-tuned CARs enhance immune cell anti-tumor activity
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma
Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
γδ T cells mediate immunotherapy responses when cancers lack MHC class I
Targeting T cell checkpoints and myeloid suppressor cells is effective in pancreatic cancer