Immunoproliferative disorders articles within Nature Communications

Featured

  • Article
    | Open Access

    Idiopathic multicentric Castleman disease (CD) is a rare and potentially fatal lymphoproliferative disorder. Authors here establish a mouse xenotransplantation model of the “not otherwise specified” subtype of the disease and show that the chemokine CXCL13 plays a pivotal role in the pathogenesis and likely produced by peripheral helper cells, which expand upon engraftment.

    • Takuya Harada
    • , Yoshikane Kikushige
    •  & Kazuyuki Yoshizaki

  • Article
    | Open Access

    B cell clonal expansion and affinity maturation takes place in germinal centers (GC) and is orchestrated by follicular T cells. Here authors show that naïve conventional T cells are continuously recruited to the GCs during the GC reaction and develop into follicular helper and regulatory T cells, thus quantitatively contribute to remodelling the GC overtime.

    • Julia Merkenschlager
    • , Riza-Maria Berz
    •  & Michel C. Nussenzweig

  • Article
    | Open Access

    Pulmonary hypertension is characterized by increased pulmonary arterial pressure, driven in part by inflammatory infiltrates. Here, the authors show that in mice, transgenic expression of mutant JAK2 leads to clonal hematopoiesis and lung accumulation of elastase- and cytokine-expressing neutrophils, and that the phenotype can be reversed by ALK1 inhibition.

    • Yusuke Kimishima
    • , Tomofumi Misaka
    •  & Yasuchika Takeishi

  • Article
    | Open Access

    XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.

    • Wan-Chen Hsieh
    • , Tzu-Sheng Hsu
    •  & Ming-Zong Lai

Browse broader subjects

Browse Immunoproliferative disorders across other nature.com journals