Immunological memory

Immunological memory refers to the ability of the immune system to respond more rapidly and effectively to a pathogen that has been encountered previously.

Latest Research and Reviews

  • Research | | open

    Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

    • Kim-Long Truong
    • , Stephan Schlickeiser
    • , Katrin Vogt
    • , David Boës
    • , Katarina Stanko
    • , Christine Appelt
    • , Mathias Streitz
    • , Gerald Grütz
    • , Nadja Stobutzki
    • , Christian Meisel
    • , Christina Iwert
    • , Stefan Tomiuk
    • , Julia K. Polansky
    • , Andreas Pascher
    • , Nina Babel
    • , Ulrik Stervbo
    • , Igor Sauer
    • , Undine Gerlach
    •  & Birgit Sawitzki
  • Research |

    Tissue-resident memory T (TRM) cells have been studied mainly in mouse models. Schumacher and colleagues have developed an imaging technology to track in real time skin-resident human CD8+ TRM cells in situ.

    • Feline E. Dijkgraaf
    • , Tiago R. Matos
    • , Mark Hoogenboezem
    • , Mireille Toebes
    • , David W. Vredevoogd
    • , Marjolijn Mertz
    • , Bram van den Broek
    • , Ji-Ying Song
    • , Marcel B. M. Teunissen
    • , Rosalie M. Luiten
    • , Joost B. Beltman
    •  & Ton N. Schumacher
    Nature Immunology 20, 756-764
  • Research |

    Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8+ T cell memory compartment.

    • Sanjivan Gautam
    • , Jessica Fioravanti
    • , Wei Zhu
    • , John B. Le Gall
    • , Philip Brohawn
    • , Neal E. Lacey
    • , Jinhui Hu
    • , James D. Hocker
    • , Nga Voong Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Devikala Gurusamy
    • , Zhiya Yu
    • , Avinash Bhandoola
    • , Hai-Hui Xue
    • , Rahul Roychoudhuri
    • , Brandon W. Higgs
    • , Nicholas P. Restifo
    • , Timothy P. Bender
    • , Yun Ji
    •  & Luca Gattinoni
    Nature Immunology 20, 337-349
  • Research |

    Cross-protective responses across all strains of influenza virus (IAV, IBV and ICV) are a key goal of universal vaccines against influenza. Kedzierska and colleagues identify cytotoxic T cells present in blood and lungs of healthy people that are directed against all strains of influenza virus.

    • Marios Koutsakos
    • , Patricia T. Illing
    • , Thi H. O. Nguyen
    • , Nicole A. Mifsud
    • , Jeremy Chase Crawford
    • , Simone Rizzetto
    • , Auda A. Eltahla
    • , E. Bridie Clemens
    • , Sneha Sant
    • , Brendon Y. Chua
    • , Chinn Yi Wong
    • , E. Kaitlynn Allen
    • , Don Teng
    • , Pradyot Dash
    • , David F. Boyd
    • , Ludivine Grzelak
    • , Weiguang Zeng
    • , Aeron C. Hurt
    • , Ian Barr
    • , Steve Rockman
    • , David C. Jackson
    • , Tom C. Kotsimbos
    • , Allen C. Cheng
    • , Michael Richards
    • , Glen P. Westall
    • , Thomas Loudovaris
    • , Stuart I. Mannering
    • , Michael Elliott
    • , Stuart G. Tangye
    • , Linda M. Wakim
    • , Jamie Rossjohn
    • , Dhanasekaran Vijaykrishna
    • , Fabio Luciani
    • , Paul G. Thomas
    • , Stephanie Gras
    • , Anthony W. Purcell
    •  & Katherine Kedzierska
    Nature Immunology 20, 613-625

News and Comment

  • News and Views |

    A novel feedback loop coordinated by germinal center–specific signaling via the kinase AKT activates negative regulators of upstream BCR signaling to attenuate responses to antigen stimulation.

    • Julie Zikherman
    Nature Immunology 20, 671-674
  • News and Views |

    The transition of the fetus from the womb to the external world represents an extraordinary challenge. The generation of memory T cells before birth may serve an important role in preparation for this fundamental transition.

    • Ai Ing Lim
    • , Oliver J. Harrison
    •  & Yasmine Belkaid
    Nature Immunology 20, 254-256
  • Research Highlights |

    TRM cells promote a melanoma–immune equilibrium that contains melanoma cells in the epidermis and prevents cancer progression.

    • Yvonne Bordon
  • Research Highlights |

    Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.

    • Laura K. Mackay