Immune tolerance

Immune tolerance is the state of unresponsiveness of the immune system to substances or tissues that have the potential to induce an immune response. Self tolerance to an individual's own antigens is achieved through both central tolerance and peripheral tolerance mechanisms.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Medullary thymic epithelial cells co-opt lineage-defining transcription factors to mimic numerous peripheral cell types and express their antigens against which maturing T cells can be tolerized.

    • Lucy Bird
  • Research Highlights |

    Lymph node colonization by tumour cells promotes subsequent spread to distant tissues by inducing broad alterations in tumour immunity and generating tumour-specific immune tolerance.

    • Lucy Bird
  • News & Views |

    Activation of resting regulatory T cells (Tregs) upon antigen encounter is essential for proper Treg function. However, the metabolic pathways that mediate this transition are unknown. Liu et al. have identified the non-oxidative pentose phosphate pathway as a central regulator of Treg activation and function.

    • Margarita Dominguez-Villar
    Nature Metabolism 4, 503-504