Immune evasion articles from across Nature Portfolio

Immune evasion is a strategy used by pathogenic organisms and tumours to evade a host's immune response to maximize their probability of being transmitted to a fresh host or to continue growing, respectively.

Latest Research and Reviews

Research
31 May 2023 | Open Access

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host
- Hannah J. Loghry
- , Hyeogsun Kwon
- & Michael J. Kimber
Scientific Reports 13, 8778
Research
22 May 2023 | Open Access

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

The cGAS-STING signalling pathway is critical in mediating host antiviral immunity. Here, Yang et al screen vaccinia viral genes to identify and then characterise that the viral protein E5 is a major inhibitor of cGAS by mediating cGAS ubiquitination and degradation.
- Ning Yang
- , Yi Wang
- & Liang Deng
Nature Communications 14, 2898
Research
11 April 2023 | Open Access

A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

Innate immune evasion is a key aspect of bacterial pathogenesis. Here, Ta et al identify and characterise EhaF, a bacterial autotransporter that functions to inhibit host innate immunity and promote the colonisation and pathogenesis of enterohemorrhagic Escherichia coli.
- Atri Ta
- , Rafael Ricci-Azevedo
- & Sivapriya Kailasan Vanaja
Nature Communications 14, 2035
Research
10 April 2023 | Open Access

Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

Antibodies against SARS-CoV-2 can be used to treat infections but there is a risk of driving viral resistance to antibodies. Here the authors characterise SARS-CoV-2 escape mutants from an immunocompromised patient treated with anti-SARS-CoV-2 antibodies using mouse protection studies and structural prediction.
- Lena Jaki
- , Sebastian Weigang
- & Jonas Fuchs
Nature Communications 14, 1999
Research
06 April 2023 | Open Access

CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3
- A-bin You
- , Hu Yang
- & Feng Ye
Cell Death & Disease 14, 245
Research
03 April 2023 | Open Access

WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis

AMPK and its downstream signaling pathways are implicated in the white spot syndrome virus (WSSV) response of the shrimp Marsupenaeus japonicus, with WSSV using this pathway to promote its proliferation.
- Peng Zhang
- , Hai-Jing Fu
- & Jin-Xing Wang
Communications Biology 6, 361

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News and Comment

Correspondence
08 May 2023 | Open Access

Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage
- Inga Nehlmeier
- , Amy Kempf
- & Markus Hoffmann
Cellular & Molecular Immunology, 1-3
Correspondence
03 March 2023 | Open Access

Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5
- Markus Hoffmann
- , Prerna Arora
- & Stefan Pöhlmann
Cellular & Molecular Immunology 20, 419-422
Correspondence | 04 January 2023

Comment on: “Evolving roles of CD38 metabolism in solid tumour microenvironment”
- Pavel Nesmiyanov
British Journal of Cancer 128, 491
Research Highlights | 10 November 2022

Differential ligand binding/trafficking for distinct CTLA-4 fates: is it an expandable mechanism?
- Ji Eon Kim
- , Eunmi Kim
- & Jung Weon Lee
Cellular & Molecular Immunology 20, 1-2
News & Views | 08 July 2022

Evolutionary insight into the emergence of SARS-CoV-2 variants of concern

Analysis of SARS-CoV-2 evolution during chronic infection reveals that in this setting, the virus evolves to bear mutations similar to those seen in variants of concern, and that many of these mutations are associated with antibody evasion. However, as mutations associated with high SARS-CoV-2 transmissibility are not observed, the emergence of variants of concern during chronic infection might be rare.

Nature Medicine 28, 1357-1358
Comments & Opinion | 08 June 2022

Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape
- Chunyan Yi
- , Xiaoyu Sun
- & Bing Sun
Cellular & Molecular Immunology 19, 848-851

All News & Comment

Immune evasion articles from across Nature Portfolio

Latest Research and Reviews

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3

WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis

News and Comment

Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage

Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5

Comment on: “Evolving roles of CD38 metabolism in solid tumour microenvironment”

Differential ligand binding/trafficking for distinct CTLA-4 fates: is it an expandable mechanism?

Evolutionary insight into the emergence of SARS-CoV-2 variants of concern

Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape

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