The hypothalamus is a brain area located below the thalamus. It consists of several nuclei with distinct functions, many of which involve regulation of the autonomic nervous system.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Ptgds-expressing neurons in the preoptic area of anterior hypothalamus detect increases in brain temperature and reduce core body temperature via increased production of prostaglandin D2.

    • Isobel Leake
  • Research Highlights |

    Neurons expressing corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus of mice show increases and decreases in activity in response to aversive and appetitive stimuli.

    • Natasha Bray
  • News and Views |

    In this issue of Nature Neuroscience, Kim and colleagues report that corticotropin-releasing factor neurons in the paraventricular nucleus, known essential regulators of the neuroendocrine axis, encode the valence of environmental stimuli through a bidirectional strategy and modulate animals’ immediate behavioral responses.

    • Rui Lin
    • , Ting Yan
    •  & Minmin Luo
    Nature Neuroscience 22, 508-510
  • News and Views |

    Hypothalamic neuronal diversity is at the core of whole-body energy-homeostasis control, but the molecular mechanisms governing neuronal neuropeptide specification remain incompletely understood. A new study in Nature Metabolism adds a relevant piece to the puzzle of how key hypothalamic neuronal populations maintain their peptidergic identity throughout the lifespan.

    • Arnaud Obri
    •  & Marc Claret
    Nature Metabolism 1, 175-176