Hypocretin articles from across Nature Portfolio

Hypocretin (also known as orexin) is a neuropeptide hormone produced in the hypothalamus that exerts important influences over sleep, arousal, appetite and energy expenditure. Defective hypocretin signalling is associated with narcolepsy.

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    The brains of individuals who have been addicted to opiate drugs show an increase in the number of hypocretin-expressing neurons — the same neurons that are lost in individuals with narcolepsy.

    • Natasha Bray