Humoral immunity articles from across Nature Portfolio

Humoral immunity refers to antibody-mediated immune responses. Antibodies are produced by plasma cells and protect the host from infection in three main ways: by binding to pathogens to inhibit their toxic effects or infectivity (neutralization), by coating pathogens and facilitating their uptake and killing by phagocytes (opsonization) and by activating the complement cascade.

Latest Research and Reviews

Research
20 March 2023 | Open Access

Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus

Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.
- Eduardo Gomez-Bañuelos
- , Yikai Yu
- & Felipe Andrade
Nature Communications 14, 1388
Research
16 March 2023 | Open Access

Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants
- Felix Wussow
- , Mindy Kha
- & Don J. Diamond
npj Vaccines 8, 41
Research
16 March 2023 | Open Access

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection through the regulation of CSR and effective clonal expansion.
- Liat Stoler-Barak
- , Ethan Harris
- & Ziv Shulman
Nature Communications 14, 1462
Research
15 March 2023 | Open Access

Characterization and utility of two monoclonal antibodies to cholera toxin B subunit
- Noel Verjan Garcia
- , Ian Carlosalberto Santisteban Celis
- & Nobuyuki Matoba
Scientific Reports 13, 4305
Research
08 March 2023 | Open Access

Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design
- Carolin Loos
- , Margherita Coccia
- & Wivine Burny
npj Vaccines 8, 34
Research
14 February 2023 | Open Access

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
- Etsuro Nanishi
- , Francesco Borriello
- & Ofer Levy
npj Vaccines 8, 18

All Research & Reviews

News and Comment

Research Highlights | 02 March 2023

Human T follicular regulatory cells with helper and regulatory lineage origins

A preprint by Le Coz et al. identifies that human T follicular regulatory cells with differences in T cell suppressive and B cell helper capacities can be derived from the regulatory T cell lineage or the T follicular helper cell lineage.
- Quang Nguyen
- & Persephone Borrow
Nature Reviews Immunology, 1
Research Highlights | 07 February 2023

How to build anti-PD1 agonist antibodies

A paper in Science Immunology describes the crucial features of agonist antibodies to the checkpoint molecule PD1.
- Alexandra Flemming
Nature Reviews Immunology 23, 139
News & Views | 19 December 2022

Simulations that capture antigen–antibody complexity

Antigen–antibody prediction remains a complex computational challenge. Simulations with the new Absolut! package provide novel insights into the models and datasets tackling this problem.
- Pieter Meysman
Nature Computational Science 2, 781-782
News & Views | 12 December 2022

Bridging the neutralization gap for unseen antibodies

Antibodies are an essential class of therapeutics but low breadth or off-target binding are major concerns for antibody–drug efficiency and safety. To predict which targets an antibody can neutralize, a machine learning pipeline based on an adaptive graph convolutional network architecture is proposed that learns the binding landscape of antibodies to multiple mutated viruses at the same time.
- Philippe A. Robert
- & Victor Greiff
Nature Machine Intelligence 5, 8-10
Research Highlights | 11 November 2022

Immature and mature antibodies as defenders against cancer
- Robin V. Lacombe
- , Sophie Sibéril
- & Jordan D. Dimitrov
Cellular & Molecular Immunology 20, 3-5
News & Views | 10 November 2022

Mouse long-lived plasma cells develop from multiple origins

By combining single-cell mRNA sequencing and a genetic pulse–chase mouse model, we identified multiple subsets of mouse long-lived plasma cells and showed that these cells can originate from diverse developmental routes.

Nature Immunology 23, 1521-1522

All News & Comment

Humoral immunity articles from across Nature Portfolio

Latest Research and Reviews

Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus

Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

Characterization and utility of two monoclonal antibodies to cholera toxin B subunit

Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

News and Comment

Human T follicular regulatory cells with helper and regulatory lineage origins

How to build anti-PD1 agonist antibodies

Simulations that capture antigen–antibody complexity

Bridging the neutralization gap for unseen antibodies

Immature and mature antibodies as defenders against cancer

Mouse long-lived plasma cells develop from multiple origins

Search

Quick links

Humoral immunity articles from across Nature Portfolio

Related Subjects

Latest Research and Reviews

News and Comment

Search

Quick links