Humoral immunity articles from across Nature Portfolio

Humoral immunity refers to antibody-mediated immune responses. Antibodies are produced by plasma cells and protect the host from infection in three main ways: by binding to pathogens to inhibit their toxic effects or infectivity (neutralization), by coating pathogens and facilitating their uptake and killing by phagocytes (opsonization) and by activating the complement cascade.

Featured

News & Views | 29 May 2023

Illuminating a blind spot in SARS-CoV-2 immunity
- Luis Graca
- , Ana Caetano Faria
- & Ruy M. Ribeiro
Nature Immunology 24, 889-890
News & Views | 22 May 2023

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

Nature Immunology, 1-2

Latest Research and Reviews

Research
06 June 2023 | Open Access

Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response
- Lynn Su
- , Wanzhi Huang
- & Timothy Palzkill
npj Vaccines 8, 87
Research
31 May 2023 | Open Access

Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization
- John T. Prior
- , Vanessa M. Limbert
- & James B. McLachlan
npj Vaccines 8, 80
Research
30 May 2023 | Open Access

Investigation of variables affecting the immunogenicity of blood group antigens using a calculation formula
- Yousun Chung
- , Han Joo Kim
- & Dae-Hyun Ko
Scientific Reports 13, 8748
Research
24 May 2023 | Open Access

Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers
- Pekka Kolehmainen
- , Moona Huttunen
- & Ilkka Julkunen
Scientific Reports 13, 8416
Research
22 May 2023 | Open Access

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

Linterman and colleagues examine germinal center formation in older individuals. They find that aged T_FH cells have dysregulated CXCR4 expression, which causes spatial mislocalization of these cells in germinal centers, impairing their ability to provide help to B cells and to promote antibody production.
- Alyssa Silva-Cayetano
- , Sigrid Fra-Bido
- & Michelle A. Linterman
Nature Immunology, 1-14
Research
18 May 2023 | Open Access

Conserved stromal–immune cell circuits secure B cell homeostasis and function

Pikor et al. show that a set of conserved, bidirectional cues exchanged between fibroblastic reticular cells and immune cells sustain B cell niches, which control humoral immune responses across mouse and human lymphoid organs.
- Mechthild Lütge
- , Angelina De Martin
- & Natalia B. Pikor
Nature Immunology, 1-12

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News and Comment

News & Views | 29 May 2023

Illuminating a blind spot in SARS-CoV-2 immunity

Indigenous populations are disproportionately affected by COVID-19, but are rarely studied. An investigation of the immune response of Australian First Nations people to SARS-CoV-2 vaccination and infection shows a major effect of comorbidities.
- Luis Graca
- , Ana Caetano Faria
- & Ruy M. Ribeiro
Nature Immunology 24, 889-890
News & Views | 22 May 2023

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T_FH) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses.

Nature Immunology, 1-2
Research Highlights | 24 April 2023

Primary vaccination imprint
- Ioana Visan
Nature Immunology 24, 732
News & Views | 23 March 2023

Fate-mapping antibodies to study sinful immune dynamics

Antibody dynamics resulting from sequential immunization are complex, limiting the study of concepts such as ‘original antigenic sin’. Here, molecular fate-mapping defines an ‘addiction’ of boosted antibodies to primary clones, and OAS-like suppression of new clones, to a degree inversely related to boosting antigenic distance.
- Joshua J. C. McGrath
- & Patrick C. Wilson
Nature Immunology 24, 570-572
Research Highlights | 23 March 2023

Reservoirs of allergic memory

Two preprints by Koenig et al. and Ota et al. characterize a subset of memory B cells that can retain allergen-specific IgE memory.
- Michelle Tran
- & Cecilia Berin
Nature Reviews Immunology 23, 272
Research Highlights | 02 March 2023

Human T follicular regulatory cells with helper and regulatory lineage origins

A preprint by Le Coz et al. identifies that human T follicular regulatory cells with differences in T cell suppressive and B cell helper capacities can be derived from the regulatory T cell lineage or the T follicular helper cell lineage.
- Quang Nguyen
- & Persephone Borrow
Nature Reviews Immunology 23, 204

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Humoral immunity articles from across Nature Portfolio

Featured

Illuminating a blind spot in SARS-CoV-2 immunity

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

Latest Research and Reviews

Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response

Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization

Investigation of variables affecting the immunogenicity of blood group antigens using a calculation formula

Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

Conserved stromal–immune cell circuits secure B cell homeostasis and function

News and Comment

Illuminating a blind spot in SARS-CoV-2 immunity

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

Primary vaccination imprint

Fate-mapping antibodies to study sinful immune dynamics

Reservoirs of allergic memory

Human T follicular regulatory cells with helper and regulatory lineage origins

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Humoral immunity articles from across Nature Portfolio

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