Homeostasis is the result of variables being regulated such that the internal environment remains stable and fairly constant even though the external environment varies. For example, in humans, the pH of blood and the internal temperature are kept reasonably constant.

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  • News and Views |

    Living organisms face the dual challenge of acquiring enough iron to perform biological functions while preventing toxic iron accretion. A study now shows that sensing of iron-catalysed free radicals by a druggable gene-regulatory pathway helps the body avoid iron poisoning.

    • Sandro Altamura
    •  & Bruno Galy
    Nature Metabolism 1, 501-502
  • News and Views |

    Interorgan communication is emerging as a critical contributor to nutrient and energy homeostasis. A new study has identified a secreted liver factor that stimulates lipid synthesis in white adipose tissue and exacerbates obesity and insulin resistance.

    • Henry Kuang
    •  & Jiandie D. Lin
    Nature Metabolism 1, 507-508
  • News and Views |

    Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors, such as nicotinamide mononucleotide (NMN), represent an exciting area of research in aging and age-related diseases. A study in Nature Metabolism provides an answer to the hotly debated yet fundamental question: how NMN actually gets into cells.

    • Lindsay E. Wu
    •  & David A. Sinclair
  • News and Views |

    Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.

    • Joshua D. Rabinowitz
    •  & Gökhan M. Mutlu