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| Open AccessIMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry
Multiplexed imaging technologies can reveal the complex cellular and molecular profiles of tissue. Here, the authors develop and implement a denoising pipeline to significantly enhance imaging mass cytometry quality and improve single-cell analyses.
- Peng Lu
- , Karolyn A. Oetjen
- & Daniel L. J. Thorek
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Article
| Open AccessA conserved tooth resorption mechanism in modern and fossil snakes
Living snakes replace their teeth without external resorption. Here, the authors use histology to show that odontoclasts resorb dentine internally and investigate this mechanism in fossil snakes.
- A. R. H. LeBlanc
- , A. Palci
- & M. W. Caldwell
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| Open AccessPermian hypercarnivore suggests dental complexity among early amniotes
Dental development and replacement rates varied greatly among early terrestrial carnivorous and herbivorous amniotes, revealing a complexity that reflected a diversity of feeding behaviours soon after their initial appearance in the fossil record.
- Tea Maho
- , Sigi Maho
- & Robert R. Reisz
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| Open AccessWhole-brain tissue mapping toolkit using large-scale highly multiplexed immunofluorescence imaging and deep neural networks
It is challenging to map complex processes in brain tissue. Here the authors report a toolkit enabling large-scale multiplexed IHC and automated cell classification whereby they use a conventional epifluorescence microscope and deep neural networks to phenotype all major cell classes of the brain.
- Dragan Maric
- , Jahandar Jahanipour
- & Badrinath Roysam
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Article
| Open AccessPostmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstruction
Studies on Patient H.M. showed that bilateral resection of the hippocampus results in impaired consolidation of long-term memory. Annese et al.create a digital map of Henry Molaison’s brain and find that a significant portion of the posterior hippocampus is actually histologically intact.
- Jacopo Annese
- , Natalie M. Schenker-Ahmed
- & Suzanne Corkin
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Histology and postural change during the growth of the ceratopsian dinosaur Psittacosaurus lujiatunensis
A few dinosaurs have been inferred to have shifted from quadrupedality to bipedality, or vice versa, during growth. Here Zhao et al. use a combination of limb measurements and analysis of limb bone cross-sections to infer a shift towards bipedality in the primitive ceratopsian Psittacosaurus lujiatunensis.
- Qi Zhao
- , Michael J. Benton
- & Xing Xu