High-throughput screening

Research related to the role of the synovium and its cell constituents during the pathogenies of osteoarthritis (OA) has taken a back seat to that of the cartilage and chondrocytes. The influence of synoviocytes in OA is increasingly recognized, but are synoviocytes equal in their contributions to disease progression?

A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.

A computational analysis of biosynthetic gene clusters with unique structural features unveils new natural product scaffolds, leading to the discovery of an antibiotic targeting BamA with activity against Gram-negative pathogens.

Leclair and Anczuków describe how high-throughput screens uncovered the connection between poison exons and cancer.

Inhibition of XPO1-mediated nuclear export by selinexor represents a promising therapeutic strategy in acute myeloid leukemia. Because XPO1 is not specific for tumor-suppressive proteins, selinexor may also activate pro-oncogenic processes. A study now shows that inhibition of selinexor-induced, purinergic receptor–mediated AKT activation potentiates its anti-leukemic activity.