Heritable quantitative trait

An heritable quantitative trait is a measurable phenotype that depends on the cumulative actions of many genes, and the environment. These traits can vary among individuals, over a range, to produce a continuous distribution of phenotypes. Examples include height, weight and blood pressure.

Latest Research and Reviews

  • Research | | open

    Prediction of face from DNA followed by matching to facial images has been proposed for forensic applications. Here, Sero et al. present a different approach that can establish facial identity from DNA without directly predicting the face but is based on classifying given faces by individual DNA-encoded traits.

    • Dzemila Sero
    • , Arslan Zaidi
    • , Jiarui Li
    • , Julie D. White
    • , Tomás B. González Zarzar
    • , Mary L. Marazita
    • , Seth M. Weinberg
    • , Paul Suetens
    • , Dirk Vandermeulen
    • , Jennifer K. Wagner
    • , Mark D. Shriver
    •  & Peter Claes
  • Research |

    By map-based cloning and knockout experiments, a study identified and validated ZmDMP to be one of the two genes known to control haploid induction in maize. A single-nucleotide mutation in ZmDMP causes a 2–3-fold increase in the haploid induction rate.

    • Yu Zhong
    • , Chenxu Liu
    • , Xiaolong Qi
    • , Yanyan Jiao
    • , Dong Wang
    • , Yuwen Wang
    • , Zongkai Liu
    • , Chen Chen
    • , Baojian Chen
    • , Xiaolong Tian
    • , Jinlong Li
    • , Ming Chen
    • , Xin Dong
    • , Xiaowei Xu
    • , Liang Li
    • , Wei Li
    • , Wenxin Liu
    • , Weiwei Jin
    • , Jinsheng Lai
    •  & Shaojiang Chen
    Nature Plants 5, 575-580
  • Reviews |

    Despite the success of human genome-wide association studies (GWAS) in associating genetic variants and complex diseases or traits, criticisms of the usefulness of this study design remain. This Review assesses the pros and cons of GWAS, with a focus on the cardiometabolic field.

    • Vivian Tam
    • , Nikunj Patel
    • , Michelle Turcotte
    • , Yohan Bossé
    • , Guillaume Paré
    •  & David Meyre
  • Research | | open

    Estimated glomerular filtration rate (eGFR) is a measure of kidney function and used to characterize chronic kidney disease. Here, Graham et al. identify 53 novel loci for eGFR in a GWAS meta-analysis, a subset of which are associated with other common diseases, such as diabetes and hypertension, based on PheWAS.

    • Sarah E. Graham
    • , Jonas B. Nielsen
    • , Matthew Zawistowski
    • , Wei Zhou
    • , Lars G. Fritsche
    • , Maiken E. Gabrielsen
    • , Anne Heidi Skogholt
    • , Ida Surakka
    • , Whitney E. Hornsby
    • , Damian Fermin
    • , Daniel B. Larach
    • , Sachin Kheterpal
    • , Chad M. Brummett
    • , Seunggeun Lee
    • , Hyun Min Kang
    • , Goncalo R. Abecasis
    • , Solfrid Romundstad
    • , Stein Hallan
    • , Matthew G. Sampson
    • , Kristian Hveem
    •  & Cristen J. Willer

News and Comment

  • Research Highlights |

    A study in Nature Genetics reports the first genome-wide significant loci for attention deficit/hyperactivity disorder and implicates biologically informative genes, such as FOXP2, as contributors to its aetiology.

    • Dorothy Clyde
  • News and Views |

    An intraspecific plant diversity experiment uncovers the mechanistic basis of a positive effect of biodiversity on biomass production, pinpointing it to a single genetic region.

    • Liesje Mommer
    •  & Jasper van Ruijven