Hepatorenal syndrome

Latest Research and Reviews

Reappraising the spectrum of AKI and hepatorenal syndrome in patients with cirrhosis

Hepatorenal syndrome type 1 (HRS-1) is a specific type of acute kidney injury (AKI) that is largely considered a functional derangement that ultimately affects renal vasculature tone. This Review describes new insights that suggest that non-haemodynamic tubulo-toxic factors, such as endotoxins and bile acids, might mediate parenchymal renal injury in patients with cirrhosis, suggesting that concurrent mechanisms might contribute to the development of AKI in patients with cirrhosis.
- Juan Carlos Q. Velez
- George Therapondos
- Luis A. Juncos
Reviews13 Nov 2019 Nature Reviews Nephrology
Volume: 16, P: 137-155
Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats
- Sabine Klein
- Franziska Frohn
- Jonel Trebicka
ResearchOpen Access19 Feb 2019 Scientific Reports
Volume: 9, P: 2256
Hepatorenal syndrome

This illustrated PrimeView focuses on the pathophysiology of acute kidney injury-hepatorenal syndrome and also discusses the diagnosis and management of this serious disorder.

Reviews13 Sept 2018 Nature Reviews Disease Primers
Volume: 4, P: 24
Hepatorenal syndrome

Hepatorenal syndrome (HRS) is defined as severe kidney functional impairment that occurs in patients with liver cirrhosis. This Primer discusses new diagnostic criteria of acute kidney injury in the context of HRS and also covers pathophysiology and management of this serious disorder.
- Pere Ginès
- Elsa Solà
- Patrick S. Kamath
Reviews13 Sept 2018 Nature Reviews Disease Primers
Volume: 4, P: 23
The evolving concept of acute kidney injury in patients with cirrhosis

Traditionally, the diagnosis of hepatorenal syndrome has been based on stringent criteria that are not ideal for patients with cirrhosis and kidney injury, leading to underdiagnosis. Acute kidney injury is now proposed to characterize renal disease in patients with cirrhosis. Florence Wong describes the evolution of these criteria that have addressed this issue and improved care for these patients.
- Florence Wong
Reviews20 Oct 2015 Nature Reviews Gastroenterology & Hepatology
Volume: 12, P: 711-719
Recent advances in our understanding of hepatorenal syndrome

Hepatorenal syndrome (HRS) is a serious complication of advanced cirrhosis with ascites. Although rare, HRS used to be a fatal condition. Improvements in our understanding of its pathophysiology, and consequent new treatments, mean that this is no longer the case. In this Review, Florence Wong summarizes the latest advances in the definition, pathophysiology, diagnosis and treatment options for HRS.
- Florence Wong
Reviews22 May 2012 Nature Reviews Gastroenterology & Hepatology
Volume: 9, P: 382-391