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Helicobacter pylori, previously named Campylobacter pylori, is a gram-negative bacterium found in the stomach. It was first isolated in 1982 from patients with chronic gastritis or gastric ulcers in Western Australia. It is also linked to the development of duodenal ulcers and stomach cancer.
The complement system is a key protective response against infectious pathogens. Here, the authors show that Helicobacter pylori uses host L-lactate to generate a complement resistant state that promotes gastric colonisation.
Increasing levels of antibiotic resistance in Helicobacter pylori are a serious threat to human health globally. This Review discusses H. pylori infection and antibiotic resistance, and provides insights into the underlying mechanisms and clinical implications (including detection and management).
A recent study found that the Helicobacter pylori genome evolves during disease progression and that these genomic changes select for effective colonizers of gastric metaplasia.
The efficacy of Helicobacter pylori eradication therapy for the prevention of preneoplastic lesions in gastric cancer remains controversial. A new placebo-controlled trial and a large-scale observational study tackle this problem and show the positive effects of eradication therapy.
