Helicobacter pylori articles within Nature Communications

Featured

• Article
  27 March 2023 | Open Access

  Helicobacter pylori initiates successful gastric colonization by utilizing L-lactate to promote complement resistance

  The complement system is a key protective response against infectious pathogens. Here, the authors show that Helicobacter pylori uses host L-lactate to generate a complement resistant state that promotes gastric colonisation.

  • Shuai Hu
  •  & Karen M. Ottemann

• Article
  04 September 2014 | Open Access

  Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection

  Chronic infection with the bacterium Helicobacter pylori is associated with inflammation and increased risk of gastric cancer. Kiga et al. show that methylation and silencing of the microRNA gene miR-210is associated with infection in humans, and promotes proliferation of gastric epithelial cells in culture.

  • Kotaro Kiga
  • , Hitomi Mimuro
  •  & Chihiro Sasakawa

• Article | 13 June 2014

  A mutation burst during the acute phase of Helicobacter pylori infection in humans and rhesus macaques

  Helicobacter pylori chronically infects humans, and this is associated with high mutation and recombination rates in the bacterium. Here the authors provide evidence that genome evolution in H. pyloriduring acute infection of the host is orders of magnitude faster than any previously determined mutation rates in bacteria.

  • Bodo Linz
  • , Helen M. Windsor
  •  & Barry J. Marshall