Health sciences

Definition

The health sciences study all aspects of health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

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Latest Research and Reviews

  • Research |

    After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.

    • Shruti Naik
    • , Samantha B. Larsen
    • , Nicholas C. Gomez
    • , Kirill Alaverdyan
    • , Ataman Sendoel
    • , Shaopeng Yuan
    • , Lisa Polak
    • , Anita Kulukian
    • , Sophia Chai
    •  & Elaine Fuchs
  • Reviews |

    Recent decades have seen an alarming rise in the incidence of autoimmune disease. In a Perspective, Matarese and colleagues discuss the evidence showing that changes in diet and metabolic workload can account for, at least in part, rises in the frequency of autoimmune disease.

    • Veronica De Rosa
    • , Antonio La Cava
    •  & Giuseppe Matarese
    Nature Immunology 18, 1190–1196
  • Reviews |

    An increasing body of evidence supports a role for B cells in the pathogenesis of type 1 diabetes mellitus (T1DM). Here, the authors discuss the mechanisms and consequences of B cell activation in T1DM and how these cells might contribute to the development of diabetic kidney disease.

    • Mia J. Smith
    • , Kimber M. Simmons
    •  & John C. Cambier
  • Reviews |

    Clinical trials are an essential aspect of drug development; however, in patients with non-castrate prostate cancer, the long natural history of the disease provides a major barrier to the introduction of new therapies. In this Review, the authors describe the potential of a novel, multi-arm, multistage, clinical trial project, with surrogate end points designed to fully reflect the effects of treatments, in transforming the treatment of patients with early stage prostate cancer, before the development of castration-resistant disease.

    • Min Yuen Teo
    • , Matthew J. O'Shaughnessy
    • , Sean M. McBride
    • , Herbert A. Vargas
    •  & Howard I. Scher
  • Research | | open

    Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.

    • Danna Sheinboim
    • , Itay Maza
    • , Iris Dror
    • , Shivang Parikh
    • , Vladislav Krupalnik
    • , Rachel E. Bell
    • , Asaf Zviran
    • , Yusuke Suita
    • , Ofir Hakim
    • , Yael Mandel-Gutfreund
    • , Mehdi Khaled
    • , Jacob H. Hanna
    •  & Carmit Levy
  • Research | | open

    The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.

    • Myriam M. Ouberai
    • , Ana L. Gomes Dos Santos
    • , Sonja Kinna
    • , Shimona Madalli
    • , David C. Hornigold
    • , David Baker
    • , Jacqueline Naylor
    • , Laura Sheldrake
    • , Dominic J. Corkill
    • , John Hood
    • , Paolo Vicini
    • , Shahid Uddin
    • , Steven Bishop
    • , Paul G. Varley
    •  & Mark E. Welland

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