Featured
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News Q&A |
Mpox vaccine rollout begins in Africa: what will success look like?
Nature talks to the mpox coordinator for Africa's public-health agency about how the continent is handling its first jabs ever.
- Max Kozlov
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Research Briefing |
A virus-derived enzyme can destroy the membrane structures that protect bacteria
Bacteria in the gut have been shown to cause the severe side effects associated with treating blood diseases with genetically dissimilar, and thus immunologically incompatible, blood stem cells (allogeneic haematopoietic cell transplantation). An enzyme derived from viruses that infect these bacteria demonstrates potential for eradication therapy.
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Nature Index |
The global imbalance of neurological conditions
Neurological conditions affect more than 40% of the population, and some countries are struggling to cope.
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Nature Index |
Neurotechnology race ramps up, but fundamental questions remain
The United States is setting the pace, but other nations are following their own paths.
- Bec Crew
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Nature Index |
High-performers and specialists in neuroscience research
An overview of the countries and institutions that dedicate a high proportion of their research to neuroscience.
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Nature Index |
United States sets the pace for implantable brain–computer interfaces
As development of the technology accelerates, countries are weighing the costs and benefits of how they regulate it.
- Liam Drew
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Nature Index |
Ones to watch: young neuroscientists on the rise
Using creative approaches and next-generation tools, these researchers hope to shed light on long-standing mysteries in neuroscience.
- Felicity Nelson
- & Benjamin Plackett
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Nature Index |
How long COVID could lift the fog on neurocognitive disorders
Insights from a new critical mass of patients are proving invaluable.
- Michael J. Peluso
- & E. Wesley Ely
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Nature Index |
Will the big neuroscience brainstorm pay off?
Investment in large neuroscience initiatives is starting to show results, but questions remain over whether they can solve the most fundamental questions about cognition.
- James Mitchell Crow
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News Feature |
Can flashing lights stall Alzheimer’s? What the science shows
Pulses of light and sound seem to have beneficial effects. But some argue it is too soon to market experimental devices.
- Elie Dolgin
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News & Views |
Hybrid protein filaments are a surprise twist in neurodegeneration
Abnormal filaments of a single type of protein are hallmarks of neurodegeneration. Structural studies reveal filaments made from two discrete but interwoven proteins, giving clues about the origin of neurodegenerative conditions.
- Michael S. Fernandopulle
- & Michael E. Ward
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News |
CRISPR helps brain stem cells regain youth in mice
Disabling a gene involved in metabolism rejuvenates cells’ ability to spin off new neurons.
- Heidi Ledford
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News |
Largest brain map ever reveals fruit fly’s neurons in exquisite detail
Wiring diagram lays out connections between nearly 140,000 neurons and reveals new types of nerve cell.
- Sara Reardon
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Article
| Open Access
Mortality caused by tropical cyclones in the United States
A large-scale evaluation of the long-term effects of tropical cyclones on human mortality in the contiguous United States estimates that the average tropical cyclone results in 7,000–11,000 excess deaths, far exceeding previous estimates.
- Rachel Young
- & Solomon Hsiang
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Correspondence |
Essential vector-disease resource faces shutdown without funding
- George K. Christophides
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News |
The huge toll of PhDs on mental health: data reveal stark effects
PhD students in Sweden accessed mental-health services at increasing rates as their studies went on.
- Fred Schwaller
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Career Feature |
Lowlands: where science meets music
At this Dutch festival, scientists learn about participants’ sex, drugs and rock-and-roll habits.
- Hannah Docter-Loeb
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News |
Revolutionary drug for schizophrenia wins US approval
The medication is the first in decades to have a different mode of action than do current drugs, achieving better symptom relief with fewer side effects.
- Elie Dolgin
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Milestones |
2021: Anti-amyloid antibodies take a bumpy road to the clinic
The arrival of the first disease-modifying therapy for Alzheimer’s was significant, but it was not met with the joy that might have been expected.
- Michael Eisenstein
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Milestones |
2020: A blood-borne biomarker for Alzheimer’s disease
The discovery and validation of a diagnostic marker in plasma could be an important step for monitoring disease progression.
- Jerome Staal
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Milestones |
1987: Finding the first Alzheimer’s gene
Mutations in the gene encoding APP, the precursor to amyloid-β, are found to underpin some cases of familial Alzheimer’s disease.
- Linda Koch
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Milestones |
2008: Exploring the role of inflammation and immunity in Alzheimer’s disease
Genetic evidence kick-starts research into the involvement of microglia cells and the innate immune system in the development of the disease.
- Kirsty Minton
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Milestones |
1999: A vaccine raises hopes of treatment for Alzheimer’s disease
Immunizing mice against amyloid-β is shown not only to prevent plaques forming, but also to clear away existing deposits.
- Lucy Bird
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Milestones |
1984: Identifying amyloid-β in brain plaques
Evidence mounts that these peptides are the key component of plaques associated with Alzheimer’s and might give rise to the disease.
- Lisa Heinke
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Milestones |
1993: A major genetic risk factor for late-onset Alzheimer’s disease
The APOE gene, which codes for a fat-binding protein in the brain, is identified as a strong genetic risk factor for the most common form of the disease.
- Henry Ertl
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Milestones |
2013: Genetic risk factors for Alzheimer’s uncovered by large meta-analysis
A study of nearly 75,000 people doubled the number of areas of the human genome that were known to be associated with late-onset disease.
- Margot Brandt
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Milestones |
1985: Disentangling tau pathology
The protein tau is identified as the core component of neurofibrillary tangles — nearly 80 years after the structures were spotted in the brains of people with Alzheimer’s disease.
- Heather Wood
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Milestones |
1906: The dawn of Alzheimer’s disease
A German physician’s study of a woman with memory loss and hallucinations marks the beginning of research into the disease that came to bear his name.
- Lisa Boucher
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Milestones |
1995: Revealing the most common cause of early-onset Alzheimer’s disease
The presenilin genes are identified as leading causes of familial disease, shedding light on an enzyme at the heart of amyloid-β production.
- Michael Attwaters
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News |
Stem cells reverse woman’s diabetes — a world first
She is the first person with type 1 diabetes to receive this kind of transplant.
- Smriti Mallapaty
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News |
This fish’s legs are made for walking — and tasting the sea floor
The northern sea robin has taste buds on its feet that can sense buried prey.
- Sara Reardon
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Outlook |
A drug-free prescription for pain
Non-invasive, non-pharmacological approaches such as virtual-reality therapy and yoga can help to relieve chronic pain.
- Carolyn Brown
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Outlook |
Pain: recognizing the power of non-pharmaceutical interventions
Physicians need alternatives to opioid drugs. Could manipulating the microbiome or virtual-reality experiences have a role in easing pain?
- Herb Brody
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Outlook |
Pain researchers must learn from the opioid crisis
A new strategy for developing analgesic drugs is needed to avoid a replay of the fiasco that led to life-shattering addictions.
- Clifford Woolf
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Outlook |
How pain is misunderstood and ignored in women
Sex hormones seem to have profound effects, but research mostly avoids the question of sex.
- Bianca Nogrady
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News Feature |
Why do obesity drugs seem to treat so many other ailments?
From alcoholism to Parkinson’s, scientists are studying the mechanisms behind the broad clinical potential of weight-loss drugs.
- Mariana Lenharo
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Outlook |
How a ‘pain-o-meter’ could improve treatments
Pain is defined subjectively, but an objective measure of the experience promises to transform its management
- Elie Dolgin
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Outlook |
The gut microbiome and chronic pain
Pain from conditions such as endometriosis could be alleviated if the gut’s resident bacteria can be understood and tamed.
- Clare Watson
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News & Views |
Childhood leukaemia in Down’s syndrome primed by blood-cell bias
An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing leukaemia.
- Sébastien Malinge
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News |
How your brain detects patterns in the everyday: without conscious thought
Neurons in certain brain areas integrate ‘what’ and ‘when’ information to discern hidden order in events in real time.
- Miryam Naddaf
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Nature Podcast |
Children with Down’s syndrome are more likely to get leukaemia: stem-cells hint at why
Restructuring of genome sections creates conditions that increase blood cancer risk — plus, the latest from the Nature Briefing.
- Benjamin Thompson
- & Emily Bates
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News |
Data integrity concerns flagged in 130 women’s health papers — all by one co-author
Some of the studies listed in a peer-reviewed paper as potentially problematic have been included in analyses that could inform clinical practice.
- Mariana Lenharo
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Article |
AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
The tRNA synthases AARS1 and AARS2 are identified as evolutionarily conserved sensors of intracellular l-lactate to mediate the global lysine lactylome.
- Heyu Li
- , Chao Liu
- & Long Zhang
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Perspective |
On human-in-the-loop optimization of human–robot interaction
A new approach to designing robotic systems that interact closely with people, called human-in-the-loop optimization, can improve human–robot interaction, but many important research questions remain before it can reach its full potential.
- Patrick Slade
- , Christopher Atkeson
- & Steven H. Collins
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Article
| Open Access
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Fc–IL-4, a typical type 2 cytokine, reinvigorates exhausted CD8+ T cells in tumours, underscoring this fusion protein as a potent immunotherapy that synergizes effectively with type 1 immunity against cancer.
- Bing Feng
- , Zhiliang Bai
- & Li Tang
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Article
| Open Access
Single-cell multi-omics map of human fetal blood in Down syndrome
Using single-cell and multi-omics data of fetal blood, a high-resolution molecular map of dysregulated haematopoiesis in Down syndrome is provided.
- Andrew R. Marderstein
- , Marco De Zuani
- & Ana Cvejic
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News & Views |
Yo-yo dieting accelerates cardiovascular disease by reprogramming the immune system
Can cycles of dieting increase your risk of heart attack? In mice, an alternating high-fat and low-fat diet promotes plaque build-up in arteries by modulating the body’s innate immune responses.
- Daniel J. Rader
- & Kate Townsend Creasy
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News Explainer |
Gaza: Why is it so hard to establish the death toll?
Body counts are a crude measure of the war’s impact and more reliable estimates will take time to compile.
- Smriti Mallapaty
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News |
COVID pandemic started in Wuhan market animals after all, suggests latest study
The finding comes from a reanalysis of genomic data.
- Smriti Mallapaty
How to keep a president healthy — tips from a former White House doctor