Gynaecological cancer

Gynaecological cancers are tumours located in the female reproductive system, and they include ovarian, uterine (or endometrial), cervical, vulval and vaginal cancer.

Latest Research and Reviews

Research
02 July 2022 | Open Access

Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma

Zhang et al. test the therapeutic potential of an inhibitor of BAD phosphorylation, NPB, in epithelial ovarian cancer. The authors show that the small molecule synergises with PARP inhibition to kill patient-derived ovarian cancer organoids and suppress the growth of xenograft tumours, including a cisplatin-resistant model.
- Xi Zhang
- , Liqiong Wang
- & Vijay Pandey
Communications Medicine 2, 82
Research
01 July 2022 | Open Access

Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix
- Shivam Shukla
- , Amar Nath Sah
- & Asima Pradhan
Scientific Reports 12, 11192
Research
01 July 2022 | Open Access

Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis
- Tatsuya Kobayashi
- , Akira Mitsuhashi
- & Makio Shozu
Scientific Reports 12, 11123
Research
01 July 2022 | Open Access

Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer
- Hugh A. Nicholson
- , Lynne Sawers
- & Gillian Smith
British Journal of Cancer, 1-12
Research
01 July 2022 | Open Access

Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis
- Hyesung Kim
- , Dong Hui Lee
- & Bogun Jang
Scientific Reports 12, 11200
Research
29 June 2022 | Open Access

Molecular characterization of low-grade serous ovarian carcinoma identifies genomic aberrations according to hormone receptor expression
- Dane Cheasley
- , Marta Llaurado Fernandez
- & Mark S. Carey
npj Precision Oncology 6, 47

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News and Comment

Research Highlights | 25 April 2022

Single vaccine shot protects against cervical cancer

A WHO expert panel concluded that a single dose of HPV vaccine has efficacy comparable to that of the two-dose regimen, which could help boost cervical cancer–elimination efforts.
- Karen O’Leary
Nature Medicine
Research Highlights | 25 February 2022

Benefit with cemiplimab in cervical cancer
- Diana Romero
Nature Reviews Clinical Oncology 19, 220
Research Highlights | 27 January 2022

Survival benefit with second-line combination in endometrial cancer
- Diana Romero
Nature Reviews Clinical Oncology 19, 149
Editorial | 19 January 2022

Melanocytic marker expression and TSC alterations/TFE3 fusions in uterine PEComas
- Robert A. Soslow
Modern Pathology 35, 449-450
Research Highlights | 14 December 2021

Cytoreductive surgery effective after relapse
- Peter Sidaway
Nature Reviews Clinical Oncology 19, 72
Research Highlights | 06 October 2021

Pembrolizumab tunes up chemotherapy in cervical cancer
- Diana Romero
Nature Reviews Clinical Oncology 18, 747

All News & Comment

Gynaecological cancer

Latest Research and Reviews

Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma

Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix

Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis

Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer

Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis

Molecular characterization of low-grade serous ovarian carcinoma identifies genomic aberrations according to hormone receptor expression

News and Comment

Single vaccine shot protects against cervical cancer

Benefit with cemiplimab in cervical cancer

Survival benefit with second-line combination in endometrial cancer

Melanocytic marker expression and TSC alterations/TFE3 fusions in uterine PEComas

Cytoreductive surgery effective after relapse

Pembrolizumab tunes up chemotherapy in cervical cancer

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