Growth factor signalling

Growth factor signalling is a cell signalling pathway that regulates the growth and development of an organism. Secreted growth factors bind to transmembrane growth factor receptors to stimulate cell signalling cascades that promote proliferation, apoptosis and differentiation.

Latest Research and Reviews

News and Comment

  • News & Views |

    mTORC1 integrates environmental signals to promote anabolism and repress catabolism. In this issue of Nature Metabolism, Hosios et al. identify a role for mTORC1 in controlling endosomal trafficking and degradation of membrane phospholipids in the lysosome, revealing a novel process used by cells to adapt to poor growth conditions.

    • Laura Tribouillard
    •  & Mathieu Laplante
    Nature Metabolism 4, 1620-1622
  • News & Views |

    EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.

    • Mary Clare Beytagh
    •  & William A. Weiss
    Nature Cell Biology 24, 1189-1191
  • News & Views |

    How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

    • Severin Mühleder
    •  & Rui Benedito
    Nature Cell Biology 23, 1109-1110
  • News & Views |

    FGFR-altered triple negative breast cancer (TNBC) develops adaptive resistance to FGFR inhibitor therapy. A new study shows that sustained FGFR inhibition causes SWI/SNF complex eviction at YAP-recruited enhancers followed by increased mTORC1 activity. Dual inhibition of YAP or mTORC1 and FGFR has a synergistic effect on tumour growth.

    • Krystal A. Orlando
    •  & Paul A. Wade
    Nature Cell Biology 23, 1115-1116