Gonads articles within Nature Communications

Featured

• Article
  10 November 2020 | Open Access

  Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

  Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.

  • LiangYu Zhao
  • , ChenCheng Yao
  •  & Zheng Li

• Article
  09 November 2020 | Open Access

  Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells

  Spermatogonia establishment in the fetal and postnatal period is essential for spermatozoa production. Here the authors present a protocol for in vitro reconstitution of human prospermatogonial specification and perform single cell RNA-sequencing to delineate lineage trajectories.

  • Young Sun Hwang
  • , Shinnosuke Suzuki
  •  & Kotaro Sasaki

• Article | 14 May 2013

  Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice

  The number of primordial follicles, which constitute the ovarian reserve, decreases with age. By overexpressing a constitutively active version of the transcription factor FOXO3, the authors increase the ovarian reserve and fertility in aging female mice.

  • Emanuele Pelosi
  • , Shakib Omari
  •  & Chris Ottolenghi

• Article | 13 November 2012

  A peptide derived from laminin-γ3 reversibly impairs spermatogenesis in rats

  The temporal opening and closing of cell–cell junctions at the blood–testis barrier allows the passage of immature germ cells during spermatogenesis. Su and colleagues identify a peptide fragment of the laminin-γ3 chain that disrupts the blood–testis barrier and reversibly impairs spermatogenesis in rats.

  • Linlin Su
  • , Dolores D. Mruk
  •  & C. Yan Cheng