Glycomics articles from across Nature Portfolio

Glycomics is a subset of the field of glycobiology that aims to identify the structure and function of the complete set of glycans (the glycome) produced in a given cell or organism and identify all the genes that encode glycoproteins.

Latest Research and Reviews

Research
23 March 2023 | Open Access

Comparative analysis of transferrin and IgG N-glycosylation in two human populations

A large-scale comparative study in two human populations analyzes human plasma transferrin and immunoglobulin G (IgG) N-glycosylation profiles and their association with age, sex, and various biochemical and physiological traits.
- Irena Trbojević-Akmačić
- , Frano Vučković
- & Gordan Lauc
Communications Biology 6, 312
Research
23 March 2023 | Open Access

Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples

Glycans can serve as disease biomarkers. Here, the authors use label-free capillary electrophoresis-mass spectrometry for N-glycan profiling of minute sample amounts, resolving and characterizing previously undetected highly sialylated glycans and linkage isomers in a single analysis.
- Anne-Lise Marie
- , Somak Ray
- & Alexander R. Ivanov
Nature Communications 14, 1618
Research
10 October 2022 | Open Access

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status
- Gang Wu
- , Paola Grassi
- & Stuart M. Haslam
Scientific Reports 12, 16948
Research
21 September 2022 | Open Access

Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi
- Laudine M. C. Petralia
- , Esrath Santha
- & Jeremy M. Foster
Scientific Reports 12, 15763
Research
06 September 2022 | Open Access

Highly sensitive characterization of non-human glycan structures of monoclonal antibody drugs utilizing tandem mass spectrometry
- Yi-Min She
- , Shaojun Dai
- & Roger Y. Tam
Scientific Reports 12, 15109
Research
01 August 2022 | Open Access

Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan

Cleavage of the glycan-branching enzyme N-acetylglucosaminyltransferase-V (GnT-V) by signal peptide peptidase-like 3 (SPPL3) protease and extracellular secretion of active glycan GnT-V depend on GnT-V’s own glycosylation state.
- Tetsuya Hirata
- , Misaki Takata
- & Yasuhiko Kizuka
Communications Biology 5, 743

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News and Comment

News | 03 October 2022

Cross-disciplinary ways to connect and blend

Jumping across silos is a tough sport. But practitioners find joy in leaving comfort zones.
- Vivien Marx
Nature Methods 19, 1149
Comments & Opinion | 08 April 2022

Advances in glycoscience to understand viral infection and colonization

Interactions between carbohydrates and the proteins that bind them (lectins) are often some of the first between a host cell and a viral invader. With its highly glycosylated spike protein, SARS-CoV-2 is no exception. Interrogating glycosylation is vital to understand viral infection, yet it has been a challenge. Improvement in methods ranging from mass spectrometry to glycan arrays and modeling simulations are yielding atomic-level information about the glycans that decorate viruses and host cells alike.
- Amanda E. Dugan
- , Amanda L. Peiffer
- & Laura L. Kiessling
Nature Methods 19, 384-387
Comments & Opinion | 06 January 2021

Glycoproteomics

Glycoproteomics is coming of age, thanks to advances in instrumentation, experimental methodologies and computational search algorithms.
- Arunima Singh
Nature Methods 18, 28
Correspondence | 22 June 2020

The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences
- Issaku Yamada
- , Masaaki Shiota
- & Kiyoko F. Aoki-Kinoshita
Nature Methods 17, 649-650
Correspondence
25 July 2018 | Open Access

Reply to ‘Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG’
- Jing-Rong Wang
- , Wei-Na Gao
- & Zhi-Hong Jiang
Nature Communications 9, 2915
Research Highlights | 30 January 2014

A method for glycan sequencing

Nature Methods 11, 129

All News & Comment

Glycomics articles from across Nature Portfolio

Latest Research and Reviews

Comparative analysis of transferrin and IgG N-glycosylation in two human populations

Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi

Highly sensitive characterization of non-human glycan structures of monoclonal antibody drugs utilizing tandem mass spectrometry

Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan

News and Comment

Cross-disciplinary ways to connect and blend

Advances in glycoscience to understand viral infection and colonization

Glycoproteomics

The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences

Reply to ‘Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG’

A method for glycan sequencing

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