Glycobiology articles within Nature

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  • Article |

    A cryo-electron microscopy analysis reveals how HAS selects its substrates, hydrolyses the first substrate to prime the synthesis reaction, opens a hyaluronan-conducting transmembrane channel, ensures alternating substrate polymerization and coordinates hyaluronan inside its transmembrane pore.

    • Finn P. Maloney
    • , Jeremi Kuklewicz
    •  & Jochen Zimmer

  • Article |

    An imaging method combining soft-landing electrospray ion beam deposition and low-temperature scanning tunnelling microscopy resolves the structures of glycans at sub-nanometre resolution, revealing the connectivity of glycan chains and the types of linkages.

    • X. Wu
    • , M. Delbianco
    •  & K. Kern

  • Article |

    Analyses reveal a previously undescribed transmembrane protein fold in the endoplasmic reticulum-based glucosyltransferase ALG6 and provide a structural basis for understanding the glucose transfer mechanism.

    • Joël S. Bloch
    • , Giorgio Pesciullesi
    •  & Kaspar P. Locher

  • Article |

    The high-resolution structure of the entire eukaryotic oligosaccharyltransferase complex is determined, revealing the role of membrane lipids in mediating inter-subunit interactions, and the mechanism by which the complex enables protein N-glycosylation.

    • Lin Bai
    • , Tong Wang
    •  & Huilin Li

  • Article |

    The hierarchical deconstruction of the complex pectic glycan rhamnogalacturonan-II by the human gut bacterium Bacteroides thetaiotaomicron reveals seven new families of glycoside hydrolases and three catalytic functions not previously observed.

    • Didier Ndeh
    • , Artur Rogowski
    •  & Harry J. Gilbert

  • Article |

    Here the authors use in crystallo enzymology to obtain structural snapshots of a complete cellulose biosynthesis cycle and reveal the mechanism by which the bacterial cellulose synthase BcsA–BcsB translocates the nascent cellulose polymer.

    • Jacob L. W. Morgan
    • , Joshua T. McNamara
    •  & Jochen Zimmer

  • Article |

    The X-ray crystal structure of the ABC transporter PglK, which facilitates the flipping of lipid-linked oligosaccharides (LLOs) in C. jejuni, in inward- and outward-facing states is solved; the structures and follow-up biochemical experiments support an unprecedented mechanism in which the polyprenyl tail of LLO remains partially embedded in the lipid bilayer, and the pyrophosphate-oligosaccharide head group is flipped into the outward-facing cavity after ATP is hydrolysed.

    • Camilo Perez
    • , Sabina Gerber
    •  & Kaspar P. Locher

  • Article |

    Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins, and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins — by funnelling integrins into adhesions, integrin clustering and signalling is promoted, which leads to enhanced cell survival and proliferation.

    • Matthew J. Paszek
    • , Christopher C. DuFort
    •  & Valerie M. Weaver

  • Article |

    An X-ray crystal structure of the bacterial cellulose synthase captures the process of cellulose synthesis and membrane translocation; the structure indicates how the synthesis of cellulose and the translocation of the nascent polysaccharide chain across the cell membrane are coupled.

    • Jacob L. W. Morgan
    • , Joanna Strumillo
    •  & Jochen Zimmer

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