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Article
| Open Access
Mucosal TLR5 activation controls healthspan and longevity
Understanding how the immune system’s functionality declines with age is crucial for addressing aging-related health issues. Here, the authors demonstrate that activating TLR5 in the mucosal layer can significantly improve healthspan and longevity, suggesting a novel approach for aging interventions.
- Jae Sung Lim
- , Eun Jae Jeon
- & Kyung A Cho
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Article
| Open Access
Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts
The association of telomere length with age and mortality across racially diverse pulmonary fibrosis populations is unknown. Here, the authors show that leukocyte telomere length associates with chronologic age and is predictive of mortality in pulmonary fibrosis across racial groups.
- Ayodeji Adegunsoye
- , Chad A. Newton
- & Imre Noth
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Article
| Open Access
Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults
Frailty is associated with an increased risk for negative health outcomes in older populations, and being able to predict frailty could facilitate prevention measures. By performing an epigenome-wide screen, the authors derived a DNA methylation based measure for frailty which can predict both prevalence and longer-term incidence of frailty.
- Xiangwei Li
- , Thomas Delerue
- & Hermann Brenner
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Article
| Open Access
Secure human action recognition by encrypted neural network inference
Advanced computer vision technology can provide near real-time home monitoring to support "aging in place” by detecting falls and symptoms related to seizures and stroke. In this paper, the authors propose a strategy that uses homomorphic encryption, which guarantees information confidentiality while retaining action detection.
- Miran Kim
- , Xiaoqian Jiang
- & Shayan Shams
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Article
| Open Access
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, which effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice without causing severe thrombocytopenia.
- Yonghan He
- , Xuan Zhang
- & Daohong Zhou
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Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Age-related macular degeneration is a prominent cause of irreversible blindness among the elderly. Here Huang et al.identify a novel missense variant in UBE3D that sheds new light on the pathogenesis of the disease.
- Lv-Zhen Huang
- , Ying-Jie Li
- & Xiao-Xin Li
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Article
| Open Access
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
T-cell responses are dysregulated in aged humans and mice, which leads to poor antitumour responses. Here, the authors demonstrate that this phenomenon is at least partially due to an overproduction of IL-6 caused by ageing and its inhibitory effect on Th1 differentiation of tumour-specific CD4 T cells.
- Hirotake Tsukamoto
- , Satoru Senju
- & Yasuharu Nishimura
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Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
As well as substantial changes in mood, geriatric depression is also characterized by executive dysfunction (ED). Morimoto et al.show that some sufferers of geriatric depression do not respond to conventional drugs, and that ED in these patients can be alleviated with computerized cognitive remediation therapy.
- Sarah Shizuko Morimoto
- , Bruce E. Wexler
- & George S. Alexopoulos
Leisure engagement in older age is related to objective and subjective experiences of aging