The genotype is the genetic makeup of a cell, organism or individual with reference to a particular characteristic. In diploid or polyploid individuals, it refers to what combination of alleles the individual carries.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    During development, cell competition causes apoptosis of cells with abnormal ribosomal protein profiles. Ji et al. show that this same mechanism also deletes aneuploid cells and that the deleted cell populations mainly have altered ribosomal protein gene dosages.

    • Caroline Barranco
  • Comments & Opinion |

    Host genetics, housing conditions, and antibiotic treatments impact microbiota diversity and composition, but microbes that inhabit the mouse gut and skin can also influence severity and penetrance of host mutant phenotypes.

    • Michelle N. Perry
    • , Susan M. Bello
    •  & Cynthia L. Smith
    Lab Animal 49, 301-302
  • Research Highlights |

    A new study has identified genetic determinants of mosaic loss of chromosome Y (LOY) in leukocytes that are also associated with increased risk of various non-haematological cancers, suggesting LOY in blood is a biomarker of genome instability in other tissues.

    • Dorothy Clyde
  • Research Highlights |

    A study in Nature emphasizes that the diversity of genetic ancestries represented by large-scale genomic studies needs to be increased in order to ensure that their findings — and any resulting advances in health care — are relevant to everyone, regardless of ethnicity.

    • Dorothy Clyde
  • Research Highlights |

    A new study reports a genome-wide polygenic score (GPS) that is predictive of obesity, thus providing opportunities for early health interventions.

    • Darren J. Burgess