Genomics

Genomics is the study of the full genetic complement of an organism (the genome). It employs recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyse the structure and function of genomes.

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Latest Research and Reviews

News and Comment

  • Research Highlights |

    The GTEx consortium reports results from its third and final phase in several new papers. They provide unprecedented detail of human gene expression regulation across tissues.

    • Darren J. Burgess
  • Research Highlights |

    A study in Molecular Biology and Evolution reports de novo genome sequences for 17 bumblebee species spanning all 15 subgenera. This valuable resource should provide a deeper biological understanding of these commercially and ecologically important pollinators.

    • Dorothy Clyde
  • Comments and Opinion |

    The Human Cell Atlas has been undergoing a massive effort to support global scientific equity. The co-leaders of its Equity Working Group share some lessons learned in the process.

    • Partha P. Majumder
    • , Musa M. Mhlanga
    •  & Alex K. Shalek
    Nature Medicine 26, 1509-1511
  • Research Highlights |

    A study in Nature Genetics reports the analysis of 172 whole-genome sequences of indigenous African cattle and identifies loci associated with environmental adaptations among crossbred animals.

    • Linda Koch
  • Comments and Opinion
    | Open Access

    In the next decade, advances in our understanding of microbes and microbiomes will likely transform our way of life; providing novel therapeutics, alternate energy sources, and shaping fundamental doctrines of biology. We explore the promises herein, and tools required to achieve this progress. Notably, it is critical that we improve the inclusivity and diversity of our research agendas and teams, so that science benefits people of all identities and backgrounds.

    • Aravind Natarajan
    •  & Ami S. Bhatt
  • News and Views |

    How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

    • Erika C. Anderson
    •  & Elphège P. Nora
    Nature Genetics 52, 1003-1004