Genomic instability

Chromosome instability describes the increased probability of acquiring chromosomal aberrations due to defects in processes such as DNA repair, replication or chromosome segregation.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    In this Journal Club article, Geoff Faulkner discusses how a ground-breaking study of LINE-1 mobility in human genomes demonstrated not just a role in disease but also molecular details of the mechanisms of retrotransposition.

    • Geoffrey J. Faulkner
  • News & Views |

    The collapse of DNA replication forks leads to the formation of single-ended DNA double-strand breaks. One would have assumed that these breaks would be repaired as soon as possible. However, a recent study suggests that a delay in DNA polymerase θ-mediated end joining until mitosis, orchestrated by BRCA2 and RAD52, favors genomic stability.

    • Michalis Petropoulos
    •  & Thanos D. Halazonetis
    Nature Cell Biology 23, 1055-1057
  • Research Highlights |

    Schep et al. show that non-homologous end joining is strongly favoured in euchromatin, whereas single-stranded template repair is moderately preferred in heterochromatin. Importantly, heterochromatin features that promote microhomology-mediated end joining also decrease Cas9 efficiency.

    • Caroline Barranco
  • News & Views |

    Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells.

    • Ali Motazedian
    •  & Mark A. Dawson
    Nature Cell Biology 23, 295-296