Genomic instability

Chromosome instability describes the increased probability of acquiring chromosomal aberrations due to defects in processes such as DNA repair, replication or chromosome segregation.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A new study has identified genetic determinants of mosaic loss of chromosome Y (LOY) in leukocytes that are also associated with increased risk of various non-haematological cancers, suggesting LOY in blood is a biomarker of genome instability in other tissues.

    • Dorothy Clyde
  • News and Views |

    Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.

    • Björn Schumacher
    •  & Jan Vijg
    Nature Metabolism 1, 931-932
  • News and Views |

    Ribonucleotides that are misincorporated into DNA during replication are removed by topoisomerase 1, which generates 3′-terminal adducts that are not amenable to DNA repair and thus compromise genome stability. A recent report by Li et al. reveals that Apn2/APE2 resolves such blocked 3′ termini, thereby suppressing topoisomerase 1–induced mutations at ribonucleotide monophosphate sites within the genome.

    • Shan Yan