Genomic analysis

Genomic analysis is the identification, measurement or comparison of genomic features such as DNA sequence, structural variation, gene expression, or regulatory and functional element annotation at a genomic scale. Methods for genomic analysis typically require high-throughput sequencing or microarray hybridization and bioinformatics.

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Latest Research and Reviews

  • Research |

    Analysis of crow admixed genomes in a European hybrid zone shows that variation in hybrid colour phenotypes is explained by recessive epistasis between two pigmentation genes, which are targets of divergent selection.

    • Ulrich Knief
    • , Christen M. Bossu
    • , Nicola Saino
    • , Bengt Hansson
    • , Jelmer Poelstra
    • , Nagarjun Vijay
    • , Matthias Weissensteiner
    •  & Jochen B. W. Wolf
  • Research |

    Matoba et al. examine genetic components of smoking behaviours in the Japanese population, identifying seven novel loci and 11 diseases that share genetic bases with smoking behaviours.

    • Nana Matoba
    • , Masato Akiyama
    • , Kazuyoshi Ishigaki
    • , Masahiro Kanai
    • , Atsushi Takahashi
    • , Yukihide Momozawa
    • , Shiro Ikegawa
    • , Masashi Ikeda
    • , Nakao Iwata
    • , Makoto Hirata
    • , Koichi Matsuda
    • , Michiaki Kubo
    • , Yukinori Okada
    •  & Yoichiro Kamatani
  • Research |

    This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

    • Laura M. Huckins
    • , Amanda Dobbyn
    • , Douglas M. Ruderfer
    • , Gabriel Hoffman
    • , Weiqing Wang
    • , Antonio F. Pardiñas
    • , Veera M. Rajagopal
    • , Thomas D. Als
    • , Hoang T. Nguyen
    • , Kiran Girdhar
    • , James Boocock
    • , Panos Roussos
    • , Menachem Fromer
    • , Robin Kramer
    • , Enrico Domenici
    • , Eric R. Gamazon
    • , Shaun Purcell
    • , Jessica S. Johnson
    • , Hardik R. Shah
    • , Lambertus L. Klein
    • , Kristen K. Dang
    • , Benjamin A. Logsdon
    • , Milind C. Mahajan
    • , Lara M. Mangravite
    • , Hiroyoshi Toyoshiba
    • , Raquel E. Gur
    • , Chang-Gyu Hahn
    • , Eric Schadt
    • , David A. Lewis
    • , Vahram Haroutunian
    • , Mette A. Peters
    • , Barbara K. Lipska
    • , Joseph D. Buxbaum
    • , Keisuke Hirai
    • , Thanneer M. Perumal
    • , Laurent Essioux
    • , Stephan Ripke
    • , Benjamin M. Neale
    • , Aiden Corvin
    • , James T. R. Walters
    • , Kai-How Farh
    • , Peter A. Holmans
    • , Phil Lee
    • , Brendan Bulik-Sullivan
    • , David A. Collier
    • , Hailiang Huang
    • , Tune H. Pers
    • , Ingrid Agartz
    • , Esben Agerbo
    • , Margot Albus
    • , Madeline Alexander
    • , Farooq Amin
    • , Silviu A. Bacanu
    • , Martin Begemann
    • , Richard A. Belliveau Jr
    • , Judit Bene
    • , Sarah E. Bergen
    • , Elizabeth Bevilacqua
    • , Tim B. Bigdeli
    • , Donald W. Black
    • , Richard Bruggeman
    • , Nancy G. Buccola
    • , Randy L. Buckner
    • , William Byerley
    • , Wiepke Cahn
    • , Guiqing Cai
    • , Dominique Campion
    • , Rita M. Cantor
    • , Vaughan J. Carr
    • , Noa Carrera
    • , Stanley V. Catts
    • , Kimberly D. Chambert
    • , Raymond C. K. Chan
    • , Ronald Y. L. Chen
    • , Eric Y. H. Chen
    • , Wei Cheng
    • , Eric F. C. Cheung
    • , Siow Ann Chong
    • , C. Robert Cloninger
    • , David Cohen
    • , Nadine Cohen
    • , Paul Cormican
    • , Nick Craddock
    • , James J. Crowley
    • , David Curtis
    • , Michael Davidson
    • , Kenneth L. Davis
    • , Franziska Degenhardt
    • , Jurgen Del Favero
    • , Ditte Demontis
    • , Dimitris Dikeos
    • , Timothy Dinan
    • , Srdjan Djurovic
    • , Gary Donohoe
    • , Elodie Drapeau
    • , Jubao Duan
    • , Frank Dudbridge
    • , Naser Durmishi
    • , Peter Eichhammer
    • , Johan Eriksson
    • , Valentina Escott-Price
    • , Laurent Essioux
    • , Ayman H. Fanous
    • , Martilias S. Farrell
    • , Josef Frank
    • , Lude Franke
    • , Robert Freedman
    • , Nelson B. Freimer
    • , Marion Friedl
    • , Joseph I. Friedman
    • , Menachem Fromer
    • , Giulio Genovese
    • , Lyudmila Georgieva
    • , Ina Giegling
    • , Paola Giusti-Rodríguez
    • , Stephanie Godard
    • , Jacqueline I. Goldstein
    • , Vera Golimbet
    • , Srihari Gopal
    • , Jacob Gratten
    • , Lieuwe de Haan
    • , Christian Hammer
    • , Marian L. Hamshere
    • , Mark Hansen
    • , Thomas Hansen
    • , Vahram Haroutunian
    • , Annette M. Hartmann
    • , Frans A. Henskens
    • , Stefan Herms
    • , Joel N. Hirschhorn
    • , Per Hoffmann
    • , Andrea Hofman
    • , Mads V. Hollegaard
    • , David M. Hougaard
    • , Masashi Ikeda
    • , Inge Joa
    • , Antonio Julia
    • , Rene S. Kahn
    • , Luba Kalaydjieva
    • , Sena Karachanak-Yankova
    • , Juha Karjalainen
    • , David Kavanagh
    • , Matthew C. Keller
    • , James L. Kennedy
    • , Andrey Khrunin
    • , Yunjung Kim
    • , Janis Klovins
    • , James A. Knowles
    • , Bettina Konte
    • , Vaidutis Kucinskas
    • , Zita Ausrele Kucinskiene
    • , Hana Kuzelova-Ptackova
    • , Anna K. Kahler
    • , Claudine Laurent
    • , Jimmy Lee Chee Keong
    • , S. Hong Lee
    • , Sophie E. Legge
    • , Bernard Lerer
    • , Miaoxin Li
    • , Tao Li
    • , Kung-Yee Liang
    • , Jeffrey Lieberman
    • , Svetlana Limborska
    • , Carmel M. Loughland
    • , Jan Lubinski
    • , Jouko Lonnqvist
    • , Milan Macek Jr
    • , Patrik K. E. Magnusson
    • , Brion S. Maher
    • , Wolfgang Maier
    • , Jacques Mallet
    • , Sara Marsal
    • , Manuel Mattheisen
    • , Morten Mattingsdal
    • , Robert W. McCarley
    • , Colm McDonald
    • , Andrew M. McIntosh
    • , Sandra Meier
    • , Carin J. Meijer
    • , Bela Melegh
    • , Ingrid Melle
    • , Raquelle I. Mesholam-Gately
    • , Andres Metspalu
    • , Patricia T. Michie
    • , Lili Milani
    • , Vihra Milanova
    • , Younes Mokrab
    • , Derek W. Morris
    • , Ole Mors
    • , Kieran C. Murphy
    • , Robin M. Murray
    • , Inez Myin-Germeys
    • , Bertram Muller-Myhsok
    • , Mari Nelis
    • , Igor Nenadic
    • , Deborah A. Nertney
    • , Gerald Nestadt
    • , Kristin K. Nicodemus
    • , Liene Nikitina-Zake
    • , Laura Nisenbaum
    • , Annelie Nordin
    • , Eadbhard O’Callaghan
    • , Colm O’Dushlaine
    • , F. Anthony O’Neill
    • , Sang-Yun Oh
    • , Ann Olincy
    • , Line Olsen
    • , Jim Van Os
    • , Christos Pantelis
    • , George N. Papadimitriou
    • , Sergi Papiol
    • , Elena Parkhomenko
    • , Michele T. Pato
    • , Tiina Paunio
    • , Milica Pejovic-Milovancevic
    • , Diana O. Perkins
    • , Olli Pietiläinen
    • , Jonathan Pimm
    • , Andrew J. Pocklington
    • , John Powell
    • , Alkes Price
    • , Ann E. Pulver
    • , Shaun M. Purcell
    • , Digby Quested
    • , Henrik B. Rasmussen
    • , Abraham Reichenberg
    • , Mark A. Reimers
    • , Alexander L. Richards
    • , Joshua L. Roffman
    • , Panos Roussos
    • , Douglas M. Ruderfer
    • , Veikko Salomaa
    • , Alan R. Sanders
    • , Ulrich Schall
    • , Christian R. Schubert
    • , Thomas G. Schulze
    • , Sibylle G. Schwab
    • , Edward M. Scolnick
    • , Rodney J. Scott
    • , Larry J. Seidman
    • , Jianxin Shi
    • , Engilbert Sigurdsson
    • , Teimuraz Silagadze
    • , Jeremy M. Silverman
    • , Kang Sim
    • , Petr Slominsky
    • , Jordan W. Smoller
    • , Hon-Cheong So
    • , Chris C. A. Spencer
    • , Eli A. Stahl
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , Elisabeth Stogmann
    • , Richard E. Straub
    • , Eric Strengman
    • , Jana Strohmaier
    • , T. Scott Stroup
    • , Mythily Subramaniam
    • , Jaana Suvisaari
    • , Dragan M. Svrakic
    • , Jin P. Szatkiewicz
    • , Erik Soderman
    • , Srinivas Thirumalai
    • , Draga Toncheva
    • , Sarah Tosato
    • , Juha Veijola
    • , John Waddington
    • , Dermot Walsh
    • , Dai Wang
    • , Qiang Wang
    • , Bradley T. Webb
    • , Mark Weiser
    • , Dieter B. Wildenauer
    • , Nigel M. Williams
    • , Stephanie Williams
    • , Stephanie H. Witt
    • , Aaron R. Wolen
    • , Emily H. M. Wong
    • , Brandon K. Wormley
    • , Hualin Simon Xi
    • , Clement C. Zai
    • , Xuebin Zheng
    • , Fritz Zimprich
    • , Naomi R. Wray
    • , Kari Stefansson
    • , Peter M. Visscher
    • , Rolf Adolfsson
    • , Ole A. Andreassen
    • , Douglas H. R. Blackwood
    • , Elvira Bramon
    • , Joseph D. Buxbaum
    • , Anders D. Børglum
    • , Sven Cichon
    • , Ariel Darvasi
    • , Enrico Domenici
    • , Hannelore Ehrenreich
    • , Tonu Esko
    • , Pablo V. Gejman
    • , Michael Gill
    • , Hugh Gurling
    • , Christina M. Hultman
    • , Nakao Iwata
    • , Assen V. Jablensky
    • , Erik G. Jonsson
    • , Kenneth S. Kendler
    • , George Kirov
    • , Jo Knight
    • , Todd Lencz
    • , Douglas F. Levinson
    • , Qingqin S. Li
    • , Jianjun Liu
    • , Anil K. Malhotra
    • , Steven A. McCarroll
    • , Andrew McQuillin
    • , Jennifer L. Moran
    • , Preben B. Mortensen
    • , Bryan J. Mowry
    • , Markus M. Nothen
    • , Roel A. Ophoff
    • , Michael J. Owen
    • , Aarno Palotie
    • , Carlos N. Pato
    • , Tracey L. Petryshen
    • , Danielle Posthuma
    • , Marcella Rietschel
    • , Brien P. Riley
    • , Dan Rujescu
    • , Pak C. Sham
    • , Pamela Sklar
    • , David St Clair
    • , Daniel R. Weinberger
    • , Jens R. Wendland
    • , Thomas Werge
    • , Mark J. Daly
    • , Patrick F. Sullivan
    • , Michael C. O’Donovan
    • , Anders D. Børglum
    • , Ditte Demontis
    • , Veera Manikandan Rajagopal
    • , Thomas D. Als
    • , Manuel Mattheisen
    • , Jakob Grove
    • , Thomas Werge
    • , Preben Bo Mortensen
    • , Carsten Bøcker Pedersen
    • , Esben Agerbo
    • , Marianne Giørtz Pedersen
    • , Ole Mors
    • , Merete Nordentoft
    • , David M. Hougaard
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Christine Søholm Hansen
    • , Ditte Demontis
    • , Anders D. Børglum
    • , James T. R. Walters
    • , Michael C. O’Donovan
    • , Patrick Sullivan
    • , Michael J. Owen
    • , Bernie Devlin
    • , Solveig K. Sieberts
    • , Nancy J. Cox
    • , Hae Kyung Im
    • , Pamela Sklar
    •  & Eli A. Stahl

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