Genetics

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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Latest Research and Reviews

News and Comment

  • News & Views |

    Maintaining ignorance to self-nucleic acids can prevent inflammatory diseases such as Aicardi–Goutières syndrome (AGS). A new study finds that mutations in LSM11 and RNU7-1, which encode components of the histone messenger RNA–preprocessing complex, cause AGS by loosening the binding of cyclic GMP–AMP synthase (cGAS) to nucleosomes, thus enabling cGAS activation and induction of type I interferons.

    • Fiachra Humphries
    •  & Katherine A. Fitzgerald
  • Comments & Opinion
    | Open Access

    Over the past 15 years, genome-wide association studies (GWASs) have generated a wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution genome-screens will continue to drive gene discovery in years ahead. Meanwhile, GWAS loci are increasingly translated into new biology and opportunities for clinical care.

    • Ruth J. F. Loos
  • Research Highlights |

    SHARE-seq, a new high-throughput, high-resolution multi-omics method described in Cell, measures chromatin accessibility and gene expression in the same cell and enables future potential gene expression (and therefore lineage choices) to be inferred from chromatin profiles.

    • Dorothy Clyde