Genetics

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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Latest Research and Reviews

News and Comment

  • Research Highlights |

    Single-cell GET-seq (scGET-seq) enables the probing of compacted as well as accessible chromatin in single cells, covering a greater portion of the genome, which provides insights into genomic and epigenetic dynamics.

    • Lei Tang
  • Editorial
    | Open Access

    Rare variants in the LMNA gene encoding nuclear lamin A/C are causal for more than a dozen diverse mendelian disorders. Defining the functional consequences of LMNA variants has been challenging given the pleiotropy of gene functions and potential pathogenic mechanisms. It is essential to develop trustworthy, scalable and rapidly deployable in vitro assays of function to enable timely assessment of missense variants that are being uncovered by high throughout next-generation sequencing.

    • Julieta Lazarte
    •  & Robert A. Hegele
  • News & Views |

    By sieving through the plant genomic literature for the last 20 years, a study uncovered a disconnection between the research locales and plants’ native ranges. Colonialism, both past and present, might be behind this disparity.

    • Fay-Wei Li
  • News & Views |

    Two analyses of long-read sequencing show that the Winters sex-ratio distorter of Drosophila has been a part of a recent gene family expansion, coupled to the appearance of suppressors, in a genomic arms race driven by satellite DNA.

    • Aaron A. Vogan