Genetics

Definition

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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Latest Research and Reviews

  • Research |

    Activating HER2 mutations are shown to confer resistance to ER-directed therapies in patients with ER+ metastatic breast cancer. Drug resistance caused by HER2 mutations was overcome by combining ER-directed therapy with a HER2 kinase inhibitor.

    • Utthara Nayar
    • , Ofir Cohen
    • , Christian Kapstad
    • , Michael S. Cuoco
    • , Adrienne G. Waks
    • , Seth A. Wander
    • , Corrie Painter
    • , Samuel Freeman
    • , Nicole S. Persky
    • , Lori Marini
    • , Karla Helvie
    • , Nelly Oliver
    • , Orit Rozenblatt-Rosen
    • , Cynthia X. Ma
    • , Aviv Regev
    • , Eric P. Winer
    • , Nancy U. Lin
    •  & Nikhil Wagle
  • Research |

    This study leverages coding variation observed among 123,136 individuals to create a detailed map of constrained coding regions in the human genome. This map may help identify critical regions within genes that, when mutated, cause embryonic lethality or severe developmental phenotypes.

    • James M. Havrilla
    • , Brent S. Pedersen
    • , Ryan M. Layer
    •  & Aaron R. Quinlan
  • Research |

    Using metabolomics and shotgun metagenomics on stool samples from individuals with and without inflammatory bowel disease, metabolites, microbial species and genes associated with disease were identified and validated in an independent cohort.

    • Eric A. Franzosa
    • , Alexandra Sirota-Madi
    • , Julian Avila-Pacheco
    • , Nadine Fornelos
    • , Henry J. Haiser
    • , Stefan Reinker
    • , Tommi Vatanen
    • , A. Brantley Hall
    • , Himel Mallick
    • , Lauren J. McIver
    • , Jenny S. Sauk
    • , Robin G. Wilson
    • , Betsy W. Stevens
    • , Justin M. Scott
    • , Kerry Pierce
    • , Amy A. Deik
    • , Kevin Bullock
    • , Floris Imhann
    • , Jeffrey A. Porter
    • , Alexandra Zhernakova
    • , Jingyuan Fu
    • , Rinse K. Weersma
    • , Cisca Wijmenga
    • , Clary B. Clish
    • , Hera Vlamakis
    • , Curtis Huttenhower
    •  & Ramnik J. Xavier
  • Research |

    A bacterial strain that requires the neurotransmitter GABA for growth was identified and used to isolate GABA-producing bacteria, including Bacteroides spp., from human stool samples; the relative abundance of Bacteroides was negatively correlated with an altered GABA-mediated response in a depression patient cohort.

    • Philip Strandwitz
    • , Ki Hyun Kim
    • , Darya Terekhova
    • , Joanne K. Liu
    • , Anukriti Sharma
    • , Jennifer Levering
    • , Daniel McDonald
    • , David Dietrich
    • , Timothy R. Ramadhar
    • , Asama Lekbua
    • , Nader Mroue
    • , Conor Liston
    • , Eric J. Stewart
    • , Marc J. Dubin
    • , Karsten Zengler
    • , Rob Knight
    • , Jack A. Gilbert
    • , Jon Clardy
    •  & Kim Lewis

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