Genetics research

Genetics research is the scientific discipline concerned with the study of the role of genes in traits such as the development of disease. It has a key role in identifying potential targets for therapeutic intervention and also in understanding genetically based variations in response to therapeutic interventions.

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Latest Research and Reviews

  • Research |

    • Julia Brinkmann
    • , Christina Lissewski
    • , Valentina Pinna
    • , Yoann Vial
    • , Francesca Pantaleoni
    • , Francesca Lepri
    • , Paola Daniele
    • , Birute Burnyte
    • , Goran Cuturilo
    • , Christine Fauth
    • , Alper Gezdirici
    • , Dieter Kotzot
    • , Elif Yılmaz Güleç
    • , Violeta Iotova
    • , Denny Schanze
    • , Francis Ramond
    • , Markéta Havlovicová
    • , Gulen Eda Utine
    • , Pelin Ozlem Simsek-Kiper
    • , Milena Stoyanova
    • , Alain Verloes
    • , Alessandro De Luca
    • , Marco Tartaglia
    • , Hélène Cavé
    •  & Martin Zenker
  • Research |

    dACE2 is a newly identified isoform of ACE2 that is unable to bind the SARS-CoV-2 spike protein. Truncated dACE2, but not full-length ACE2, is induced by interferons and viruses, thus suggesting that such conditions are unlikely to increase cellular entry of SARS-CoV-2.

    • Olusegun O. Onabajo
    • , A. Rouf Banday
    • , Megan L. Stanifer
    • , Wusheng Yan
    • , Adeola Obajemu
    • , Deanna M. Santer
    • , Oscar Florez-Vargas
    • , Helen Piontkivska
    • , Joselin M. Vargas
    • , Timothy J. Ring
    • , Carmon Kee
    • , Patricio Doldan
    • , D. Lorne Tyrrell
    • , Juan L. Mendoza
    • , Steeve Boulant
    •  & Ludmila Prokunina-Olsson
  • Research |

    By integrating healthcare and exome-sequencing data from parent–offspring trios of patients with developmental disorders, 28 genes that had not previously been associated with developmental disorders were identified.

    • Joanna Kaplanis
    • , Kaitlin E. Samocha
    • , Laurens Wiel
    • , Zhancheng Zhang
    • , Kevin J. Arvai
    • , Ruth Y. Eberhardt
    • , Giuseppe Gallone
    • , Stefan H. Lelieveld
    • , Hilary C. Martin
    • , Jeremy F. McRae
    • , Patrick J. Short
    • , Rebecca I. Torene
    • , Elke de Boer
    • , Petr Danecek
    • , Eugene J. Gardner
    • , Ni Huang
    • , Jenny Lord
    • , Iñigo Martincorena
    • , Rolph Pfundt
    • , Margot R. F. Reijnders
    • , Alison Yeung
    • , Helger G. Yntema
    • , Silvia Borras
    • , Caroline Clark
    • , John Dean
    • , Zosia Miedzybrodzka
    • , Alison Ross
    • , Stephen Tennant
    • , Tabib Dabir
    • , Deirdre Donnelly
    • , Mervyn Humphreys
    • , Alex Magee
    • , Vivienne McConnell
    • , Shane McKee
    • , Susan McNerlan
    • , Patrick J. Morrison
    • , Gillian Rea
    • , Fiona Stewart
    • , Trevor Cole
    • , Nicola Cooper
    • , Lisa Cooper-Charles
    • , Helen Cox
    • , Lily Islam
    • , Joanna Jarvis
    • , Rebecca Keelagher
    • , Derek Lim
    • , Dominic McMullan
    • , Jenny Morton
    • , Swati Naik
    • , Mary O’Driscoll
    • , Kai-Ren Ong
    • , Deborah Osio
    • , Nicola Ragge
    • , Sarah Turton
    • , Julie Vogt
    • , Denise Williams
    • , Simon Bodek
    • , Alan Donaldson
    • , Alison Hills
    • , Karen Low
    • , Ruth Newbury-Ecob
    • , Andrew M. Norman
    • , Eileen Roberts
    • , Ingrid Scurr
    • , Sarah Smithson
    • , Madeleine Tooley
    • , Steve Abbs
    • , Ruth Armstrong
    • , Carolyn Dunn
    • , Simon Holden
    • , Soo-Mi Park
    • , Joan Paterson
    • , Lucy Raymond
    • , Evan Reid
    • , Richard Sandford
    • , Ingrid Simonic
    • , Marc Tischkowitz
    • , Geoff Woods
    • , Lisa Bradley
    • , Joanne Comerford
    • , Andrew Green
    • , Sally Lynch
    • , Shirley McQuaid
    • , Brendan Mullaney
    • , Jonathan Berg
    • , David Goudie
    • , Eleni Mavrak
    • , Joanne McLean
    • , Catherine McWilliam
    • , Eleanor Reavey
    • , Tara Azam
    • , Elaine Cleary
    • , Andrew Jackson
    • , Wayne Lam
    • , Anne Lampe
    • , David Moore
    • , Mary Porteous
    • , Emma Baple
    • , Júlia Baptista
    • , Carole Brewer
    • , Bruce Castle
    • , Emma Kivuva
    • , Martina Owens
    • , Julia Rankin
    • , Charles Shaw-Smith
    • , Claire Turner
    • , Peter Turnpenny
    • , Carolyn Tysoe
    • , Therese Bradley
    • , Rosemarie Davidson
    • , Carol Gardiner
    • , Shelagh Joss
    • , Esther Kinning
    • , Cheryl Longman
    • , Ruth McGowan
    • , Victoria Murday
    • , Daniela Pilz
    • , Edward Tobias
    • , Margo Whiteford
    • , Nicola Williams
    • , Angela Barnicoat
    • , Emma Clement
    • , Francesca Faravelli
    • , Jane Hurst
    • , Lucy Jenkins
    • , Wendy Jones
    • , V. K. Ajith Kumar
    • , Melissa Lees
    • , Sam Loughlin
    • , Alison Male
    • , Deborah Morrogh
    • , Elisabeth Rosser
    • , Richard Scott
    • , Louise Wilson
    • , Ana Beleza
    • , Charu Deshpande
    • , Frances Flinter
    • , Muriel Holder
    • , Melita Irving
    • , Louise Izatt
    • , Dragana Josifova
    • , Shehla Mohammed
    • , Aneta Molenda
    • , Leema Robert
    • , Wendy Roworth
    • , Deborah Ruddy
    • , Mina Ryten
    • , Shu Yau
    • , Christopher Bennett
    • , Moira Blyth
    • , Jennifer Campbell
    • , Andrea Coates
    • , Angus Dobbie
    • , Sarah Hewitt
    • , Emma Hobson
    • , Eilidh Jackson
    • , Rosalyn Jewell
    • , Alison Kraus
    • , Katrina Prescott
    • , Eamonn Sheridan
    • , Jenny Thomson
    • , Kirsty Bradshaw
    • , Abhijit Dixit
    • , Jacqueline Eason
    • , Rebecca Haines
    • , Rachel Harrison
    • , Stacey Mutch
    • , Ajoy Sarkar
    • , Claire Searle
    • , Nora Shannon
    • , Abid Sharif
    • , Mohnish Suri
    • , Pradeep Vasudevan
    • , Natalie Canham
    • , Ian Ellis
    • , Lynn Greenhalgh
    • , Emma Howard
    • , Victoria Stinton
    • , Andrew Swale
    • , Astrid Weber
    • , Siddharth Banka
    • , Catherine Breen
    • , Tracy Briggs
    • , Emma Burkitt-Wright
    • , Kate Chandler
    • , Jill Clayton-Smith
    • , Dian Donnai
    • , Sofia Douzgou
    • , Lorraine Gaunt
    • , Elizabeth Jones
    • , Bronwyn Kerr
    • , Claire Langley
    • , Kay Metcalfe
    • , Audrey Smith
    • , Ronnie Wright
    • , David Bourn
    • , John Burn
    • , Richard Fisher
    • , Steve Hellens
    • , Alex Henderson
    • , Tara Montgomery
    • , Miranda Splitt
    • , Volker Straub
    • , Michael Wright
    • , Simon Zwolinski
    • , Zoe Allen
    • , Birgitta Bernhard
    • , Angela Brady
    • , Claire Brooks
    • , Louise Busby
    • , Virginia Clowes
    • , Neeti Ghali
    • , Susan Holder
    • , Rita Ibitoye
    • , Emma Wakeling
    • , Edward Blair
    • , Jenny Carmichael
    • , Deirdre Cilliers
    • , Susan Clasper
    • , Richard Gibbons
    • , Usha Kini
    • , Tracy Lester
    • , Andrea Nemeth
    • , Joanna Poulton
    • , Sue Price
    • , Debbie Shears
    • , Helen Stewart
    • , Andrew Wilkie
    • , Shadi Albaba
    • , Duncan Baker
    • , Meena Balasubramanian
    • , Diana Johnson
    • , Michael Parker
    • , Oliver Quarrell
    • , Alison Stewart
    • , Josh Willoughby
    • , Charlene Crosby
    • , Frances Elmslie
    • , Tessa Homfray
    • , Huilin Jin
    • , Nayana Lahiri
    • , Sahar Mansour
    • , Karen Marks
    • , Meriel McEntagart
    • , Anand Saggar
    • , Kate Tatton-Brown
    • , Rachel Butler
    • , Angus Clarke
    • , Sian Corrin
    • , Andrew Fry
    • , Arveen Kamath
    • , Emma McCann
    • , Hood Mugalaasi
    • , Caroline Pottinger
    • , Annie Procter
    • , Julian Sampson
    • , Francis Sansbury
    • , Vinod Varghese
    • , Diana Baralle
    • , Alison Callaway
    • , Emma J. Cassidy
    • , Stacey Daniels
    • , Andrew Douglas
    • , Nicola Foulds
    • , David Hunt
    • , Mira Kharbanda
    • , Katherine Lachlan
    • , Catherine Mercer
    • , Lucy Side
    • , I. Karen Temple
    • , Diana Wellesley
    • , Lisenka E. L. M. Vissers
    • , Jane Juusola
    • , Caroline F. Wright
    • , Han G. Brunner
    • , Helen V. Firth
    • , David R. FitzPatrick
    • , Jeffrey C. Barrett
    • , Matthew E. Hurles
    • , Christian Gilissen
    •  & Kyle Retterer
    Nature, 1-7
  • Research |

    • Barbara Mora
    • , Claudia Siracusa
    • , Elisa Rumi
    • , Margherita Maffioli
    • , Ilaria Carola Casetti
    • , Daniela Barraco
    • , Michele Merli
    • , Marianna Rossi
    • , Marta Ubezio
    • , Raffaella Accetta
    • , Laura Libera
    • , Daniela Pietra
    • , Chiara Trotti
    • , Silvia Uccella
    • , Francesco Pallotti
    • , Rosario Casalone
    • , Lorenza Bertù
    • , Luca Arcaini
    • , Matteo Giovanni Della Porta
    •  & Francesco Passamonti
    Leukemia, 1-4

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