Genetics of the nervous system articles from across Nature Portfolio

Genetics of the nervous system refers to the study of genetics affecting the development, physiology and functions of the nervous system and diseases thereof.

Latest Research and Reviews

Research
05 June 2023 | Open Access

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank
- Daniel E. Vosberg
- , Zdenka Pausova
- & Tomáš Paus
Scientific Reports 13, 9109
Research
03 June 2023 | Open Access

A single-cell trajectory atlas of striatal development
- Ashley G. Anderson
- , Ashwinikumar Kulkarni
- & Genevieve Konopka
Scientific Reports 13, 9031
Research
24 May 2023 | Open Access

APOE ɛ4, but not polygenic Alzheimer’s disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals
- Sofia Håglin
- , Elise Koch
- & Karolina Kauppi
Scientific Reports 13, 8433
Research
12 May 2023 | Open Access

Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation
- Zsuliet Kristof
- , Zsofia Gal
- & Xenia Gonda
Scientific Reports 13, 7757
Research
11 May 2023 | Open Access

A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion
- Neha Paranjape
- , Yu-Hsiu T. Lin
- & Arun P. Wiita
Scientific Reports 13, 7689
Research | 28 April 2023

Expanding the phenotypic spectrum and clinical severity associated with WLS gene
- Ghada M. H. Abdel-Salam
- , Hanan H. Afifi
- & Hanno J. Bolz
Journal of Human Genetics, 1-7

All Research & Reviews

News and Comment

Comments & Opinion | 30 March 2023

A fresh cup of DCAF: DCAF13 implicated in a neuromuscular disorder
- Aniket Bhattacharya
European Journal of Human Genetics 31, 613-614
Research Highlights | 29 November 2022

A shared pathway connects schizophrenia and bipolar disorder

Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder.
- Jake Rogers
Nature Reviews Neuroscience 24, 2
News & Views | 30 May 2022

Robust adult neurogenesis in the primate hippocampus

The extent to which neurogenesis occurs in adult primates is still controversial. Single-cell RNA sequencing, immunofluorescence staining, and ex vivo neurosphere culture experiments were performed using the adult macaque hippocampus. The results reveal robust adult neurogenesis in the dentate gyrus of the primate hippocampus.

Nature Neuroscience 25, 684-685
Research Highlights | 26 May 2022

Sex differences of oestradiol-mediated gene expression

Gegenhuber et al. now show that, in mice, a neonatal surge in oestradiol activates oestrogen receptor-α to drive a sustained male-typical gene expression programme that determines brain sexual differentiation.
- Katharine H. Wrighton
Nature Reviews Genetics 23, 391
Research Highlights | 15 March 2022

A cryptic fault

Two studies identify a mechanism linking TDP-43 pathology with genetic variants associated with increased risk of neurodegenerative disorders.
- Natasha Bray
Nature Reviews Neuroscience 23, 255
Research Highlights | 22 February 2022

Primed and ready

Immune genes implicated in multiple sclerosis pathology are shown to be primed but not expressed in oligodendrocyte precursor cells in both mouse and human.
- Sian Lewis
Nature Reviews Neuroscience 23, 189

All News & Comment

Genetics of the nervous system articles from across Nature Portfolio

Latest Research and Reviews

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank

A single-cell trajectory atlas of striatal development

APOE ɛ4, but not polygenic Alzheimer’s disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals

Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation

A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion

Expanding the phenotypic spectrum and clinical severity associated with WLS gene

News and Comment

A fresh cup of DCAF: DCAF13 implicated in a neuromuscular disorder

A shared pathway connects schizophrenia and bipolar disorder

Robust adult neurogenesis in the primate hippocampus

Sex differences of oestradiol-mediated gene expression

A cryptic fault

Primed and ready

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