Genetic linkage study articles within Nature Communications

Featured

• Article
  28 September 2023 | Open Access

  Cloning of the wheat leaf rust resistance gene Lr47 introgressed from Aegilops speltoides

  Leaf rust is one of the most severe foliar diseases of wheat. Here, the authors report the cloning of Lr47, a broadly effective leaf rust resistance gene introgressed into wheat from Aegilops speltoides, and show it encodes a coiled-coil nucleotide-binding leucine-rich repeat protein.

  • Hongna Li
  • , Lei Hua
  •  & Shisheng Chen

• Article
  01 June 2022 | Open Access

  Cloning of the broadly effective wheat leaf rust resistance gene Lr42 transferred from Aegilops tauschii

  The Aegilops tauschii-derived leaf rust resistance gene Lr42 has been widely used for breeding resistance wheat cultivars, but the molecular basis is unknown. Here, the authors show that Lr42 encodes an NLR-type of disease resistance gene by bulked segregant mapping in Ae. tauschii and confirm its function in common wheat.

  • Guifang Lin
  • , Hui Chen
  •  & Sanzhen Liu

• Article
  14 April 2022 | Open Access

  Chromosome evolution and the genetic basis of agronomically important traits in greater yam

  While greater yam provides food and income security for millions of people around the world, there are limited genomic resources available. Here, the authors report a chromosome-scale assembly of the greater yam genome as well as quantitative trait loci associated with anthracnose resistance and tuber traits.

  • Jessen V. Bredeson
  • , Jessica B. Lyons
  •  & Daniel S. Rokhsar

• Article
  18 March 2022 | Open Access

  The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross

  Heritable traits can be affected by additive, dominance, and epistatic effects at genetic loci. Here, the authors use chromosomally-encoded barcodes to perform linkage mapping in diploid cross progeny in budding yeast, finding that epistasis in diploids frequently modifies both additivity and dominance.

  • Takeshi Matsui
  • , Martin N. Mullis
  •  & Ian M. Ehrenreich

• Article
  06 September 2019 | Open Access

  An ancestral NB-LRR with duplicated 3′UTRs confers stripe rust resistance in wheat and barley

  Stripe rust is a serious threat to wheat production. Here, the authors reveal that the resistance gene, only present in the wheat progenitor Aegilops tauschii and its derived synthetic wheat, encodes a nucleotide oligomerization domain-like receptor and confers resistance in common wheat and barley.

  • Chaozhong Zhang
  • , Lin Huang
  •  & Daolin Fu

• Article
  18 June 2019 | Open Access

  Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

  QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.

  • Alejandro Burga
  • , Eyal Ben-David
  •  & Leonid Kruglyak

• Article
  17 September 2018 | Open Access

  The complex underpinnings of genetic background effects

  Mutations often show distinct phenotypic effects across different genetic backgrounds. Here the authors describe the genetic basis of these so-called background effects using data on genotype and growth in 10 environments from 1411 segregants from a cross of two strains of budding yeast.

  • Martin N. Mullis
  • , Takeshi Matsui
  •  & Ian M. Ehrenreich

• Article
  30 January 2018 | Open Access

  Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database

  Programs such as PolyPhen-2 predict the relative severity of damage by missense mutations. Here, Wang et al estimate probabilities that putative null or missense alleles would reduce protein function to cause detectable phenotype by analyzing data from ENU-induced mouse mutations.

  • Tao Wang
  • , Chun Hui Bu
  •  & Bruce Beutler

• Article
  02 November 2016 | Open Access

  Powerful decomposition of complex traits in a diploid model

  Dissecting the architecture of complex trait is challenging. Here, Hallin, Märtens et al. devises Phased Outbred Lines (POLs) in order to accurately decompose growth trait variation in diploid yeast across different environments.

  • Johan Hallin
  • , Kaspar Märtens
  •  & Gianni Liti

• Article
  22 July 2016 | Open Access

  Genetic lineage tracing defines myofibroblast origin and function in the injured heart

  The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert back to a less-activated state upon injury resolution.

  • Onur Kanisicak
  • , Hadi Khalil
  •  & Jeffery D. Molkentin