Genetic linkage study

  • Article
    | Open Access

    QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.

    • Alejandro Burga
    • , Eyal Ben-David
    •  & Leonid Kruglyak
  • Article
    | Open Access

    Mutations often show distinct phenotypic effects across different genetic backgrounds. Here the authors describe the genetic basis of these so-called background effects using data on genotype and growth in 10 environments from 1411 segregants from a cross of two strains of budding yeast.

    • Martin N. Mullis
    • , Takeshi Matsui
    •  & Ian M. Ehrenreich
  • Article
    | Open Access

    Dissecting the architecture of complex trait is challenging. Here, Hallin, Märtens et al. devises Phased Outbred Lines (POLs) in order to accurately decompose growth trait variation in diploid yeast across different environments.

    • Johan Hallin
    • , Kaspar Märtens
    •  & Gianni Liti
  • Article
    | Open Access

    The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert back to a less-activated state upon injury resolution.

    • Onur Kanisicak
    • , Hadi Khalil
    •  & Jeffery D. Molkentin