Genetic circuit engineering articles within Nature

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• Letter | 19 June 2019

  A universal biomolecular integral feedback controller for robust perfect adaptation

  A synthetic gene circuit implementing an integral feedback topology is shown to achieve robust perfect adaptation in living cells--mathematical analysis proves this topology is necessary for adaptation in networks with noisy dynamics.

  • Stephanie K. Aoki
  • , Gabriele Lillacci
  •  & Mustafa Khammash

• Article | 10 November 2010

  Genetic dissection of an amygdala microcircuit that gates conditioned fear

  The central amygdala relies on inhibitory circuitry to encode fear memories, but how this information is acquired and expressed in these connections is unknown. Two new papers use a combination of cutting-edge technologies to reveal two distinct microcircuits within the central amygdala, one required for fear acquisition and the other critical for conditioned fear responses. Understanding this architecture provides a strong link between activity in a specific circuit and particular behavioural consequences.

  • Wulf Haubensak
  • , Prabhat S. Kunwar
  •  & David J. Anderson

• Article | 21 January 2010

  A synchronized quorum of genetic clocks

  A defining focus of synthetic biology is the engineering of genetic circuits with predictive functionality in living cells. Here, a decade after the first synthesized genetic toggle switch and oscillator, an engineered gene network with global intercellular coupling is designed that is capable of generating synchronized oscillations in a growing population of cells.

  • Tal Danino
  • , Octavio Mondragón-Palomino
  •  & Jeff Hasty