Gene regulation in immune cells

Gene regulation in immune cells refers to the mechanisms used by immune cells to increase or decrease the production of specific gene products.

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Latest Research and Reviews

  • Research | | open

    Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.

    • Simon H. Jiang
    • , Vicki Athanasopoulos
    • , Julia I. Ellyard
    • , Aaron Chuah
    • , Jean Cappello
    • , Amelia Cook
    • , Savit B. Prabhu
    • , Jacob Cardenas
    • , Jinghua Gu
    • , Maurice Stanley
    • , Jonathan A. Roco
    • , Ilenia Papa
    • , Mehmet Yabas
    • , Giles D. Walters
    • , Gaetan Burgio
    • , Kathryn McKeon
    • , James M. Byers
    • , Charlotte Burrin
    • , Anselm Enders
    • , Lisa A. Miosge
    • , Pablo F. Canete
    • , Marija Jelusic
    • , Velibor Tasic
    • , Adrian C. Lungu
    • , Stephen I. Alexander
    • , Arthur R. Kitching
    • , David A. Fulcher
    • , Nan Shen
    • , Todor Arsov
    • , Paul A. Gatenby
    • , Jeff J. Babon
    • , Dominic F. Mallon
    • , Carmen de Lucas Collantes
    • , Eric A. Stone
    • , Philip Wu
    • , Matthew A. Field
    • , Thomas D. Andrews
    • , Eun Cho
    • , Virginia Pascual
    • , Matthew C. Cook
    •  & Carola G. Vinuesa
  • Research | | open

    Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.

    • John A. Lees
    • , Bart Ferwerda
    • , Philip H. C. Kremer
    • , Nicole E. Wheeler
    • , Mercedes Valls Serón
    • , Nicholas J. Croucher
    • , Rebecca A. Gladstone
    • , Hester J. Bootsma
    • , Nynke Y. Rots
    • , Alienke J. Wijmega-Monsuur
    • , Elisabeth A. M. Sanders
    • , Krzysztof Trzciński
    • , Anne L. Wyllie
    • , Aeilko H. Zwinderman
    • , Leonard H. van den Berg
    • , Wouter van Rheenen
    • , Jan H. Veldink
    • , Zitta B. Harboe
    • , Lene F. Lundbo
    • , Lisette C. P. G. M. de Groot
    • , Natasja M. van Schoor
    • , Nathalie van der Velde
    • , Lars H. Ängquist
    • , Thorkild I. A. Sørensen
    • , Ellen A. Nohr
    • , Alexander J. Mentzer
    • , Tara C. Mills
    • , Julian C. Knight
    • , Mignon du Plessis
    • , Susan Nzenze
    • , Jeffrey N. Weiser
    • , Julian Parkhill
    • , Shabir Madhi
    • , Thomas Benfield
    • , Anne von Gottberg
    • , Arie van der Ende
    • , Matthijs C. Brouwer
    • , Jeffrey C. Barrett
    • , Stephen D. Bentley
    •  & Diederik van de Beek
  • Research | | open

    Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells that shows sexually dimorphic expression.

    • Christopher A. Odhams
    • , Amy L. Roberts
    • , Susan K. Vester
    • , Carolina S. T. Duarte
    • , Charlie T. Beales
    • , Alexander J. Clarke
    • , Sonja Lindinger
    • , Samuel J. Daffern
    • , Antonino Zito
    • , Lingyan Chen
    • , Leonardo L. Jones
    • , Lora Boteva
    • , David L. Morris
    • , Kerrin S. Small
    • , Michelle M. A. Fernando
    • , Deborah S. Cunninghame Graham
    •  & Timothy J. Vyse
  • Research | | open

    The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.

    • Yun Ji
    • , Jessica Fioravanti
    • , Wei Zhu
    • , Hongjun Wang
    • , Tuoqi Wu
    • , Jinhui Hu
    • , Neal E. Lacey
    • , Sanjivan Gautam
    • , John B. Le Gall
    • , Xia Yang
    • , James D. Hocker
    • , Thelma M. Escobar
    • , Shan He
    • , Stefania Dell’Orso
    • , Nga V. Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Luciano Di Croce
    • , Stefan A. Muljo
    • , Yi Zhang
    • , Vittorio Sartorelli
    •  & Luca Gattinoni
  • Research |

    Natural killer cells have important roles in virus and anti-cancer responses. Glimcher and colleagues demonstrate that a natural killer cell-intrinsic endoplasmic reticulum stress pathway is essential for their proper function.

    • Han Dong
    • , Nicholas M. Adams
    • , Yichi Xu
    • , Jin Cao
    • , David S. J. Allan
    • , James R. Carlyle
    • , Xi Chen
    • , Joseph C. Sun
    •  & Laurie H. Glimcher

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