Gene regulation in immune cells

Gene regulation in immune cells refers to the mechanisms used by immune cells to increase or decrease the production of specific gene products.

Latest Research and Reviews

News and Comment

  • News & Views |

    Two studies reveal a role for the transcriptional regulator BATF3 as a T cell–intrinsic factor mediating effective memory responses. This finding opens future avenues of investigation and opportunities to enhance cellular immunotherapy.

    • Caleb A. Lareau
    •  & Ansuman T. Satpathy
    Nature Immunology 21, 1309-1310
  • Research Highlights |

    Histone deacetylases are typically involved in transcriptional repression, but a report in Nature describes a mechanism by which HDAC3 can also activate macrophage transcription in response to lipopolysaccharide in a deacetylase-independent manner.

    • Kirsty Minton
  • News & Views |

    The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal center B cells toward a memory B cell phenotype during viral infection.

    • Kim L. Good-Jacobson
    •  & Joanna R. Groom
    Nature Immunology 21, 968-969
  • Comments & Opinion |

    In October 2005, we, alongside the laboratory of Casey Weaver, identified a third type of helper T cells that produce the cytokine IL-17, important for the regulation of tissue inflammation.

    • Chen Dong
    Nature Immunology 21, 821-822