Gene regulation in immune cells

Gene regulation in immune cells refers to the mechanisms used by immune cells to increase or decrease the production of specific gene products.

Latest Research and Reviews

News and Comment

  • Comments & Opinion |

    Anjana Rao describes the team effort to define the changes in chromatin accessibility in naive T cells during TH1 and TH2 cell differentiation after stimulation with TCR ligands and the appropriate cytokines. Her lab showed that differentiated TH1 and TH2 cells, which produce the cytokines IFN-γ and IL-4, respectively, displayed distinct patterns of DNase I hypersensitivity, histone acetylation and NFAT1 transcription factor binding around the Ifng and Il4 genes. This project turned them into a ‘real’ immunology lab!

    • Anjana Rao
    Nature Immunology 21, 1473-1476
  • News & Views |

    Two studies reveal a role for the transcriptional regulator BATF3 as a T cell–intrinsic factor mediating effective memory responses. This finding opens future avenues of investigation and opportunities to enhance cellular immunotherapy.

    • Caleb A. Lareau
    •  & Ansuman T. Satpathy
    Nature Immunology 21, 1309-1310
  • Research Highlights |

    Histone deacetylases are typically involved in transcriptional repression, but a report in Nature describes a mechanism by which HDAC3 can also activate macrophage transcription in response to lipopolysaccharide in a deacetylase-independent manner.

    • Kirsty Minton
  • News & Views |

    The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal center B cells toward a memory B cell phenotype during viral infection.

    • Kim L. Good-Jacobson
    •  & Joanna R. Groom
    Nature Immunology 21, 968-969