Gastroparesis

Gastroparesis is chronic, delayed gastric emptying in which food remains in the stomach longer than normal; symptoms include nausea and vomiting. Gastroparesis can occur as a result of motor dysfunction, nerve damage or paralysis of the stomach muscles, and is associated with other systemic diseases (diabetes mellitus) and surgical complications (gastrectomy).

Latest Research and Reviews

  • Reviews |

    Gastroparesis is a chronic disorder characterized by gastric neuromuscular dysfunction, which causes delayed gastric emptying that is associated with symptoms of nausea and vomiting. This Primer describes different causes of gastroparesis and highlights specific diagnostic tests and management strategies.

    • Michael Camilleri
    • , Victor Chedid
    • , Alexander C. Ford
    • , Ken Haruma
    • , Michael Horowitz
    • , Karen L. Jones
    • , Phillip A. Low
    • , Seon-Young Park
    • , Henry P. Parkman
    •  & Vincenzo Stanghellini
  • Reviews |

    The gastrointestinal hormones ghrelin and motilin are released during hunger to stimulate appetite and interdigestive movement of the stomach, respectively. Ghrelin and motilin receptor agonists also increase gastric emptying of meals and emerging data shows previously unknown effects on nausea and constipation. In this Review, Sanger and Furness describe the complex interactions of ghrelin and motilin with their receptors and the pathways influencing gastrointestinal functions. Finally, they describe the potential of receptor agonists to treat various gastrointestinal disorders.

    • Gareth J. Sanger
    •  & John B. Furness
  • Reviews |

    Disordered gastric emptying (also known as gastroparesis) is a complication frequently associated with long-standing type 1 diabetes mellitus and type 2 diabetes mellitus. In this Review, Phillips and colleagues discuss the underlying pathophysiology of gastroparesis in patients with diabetes mellitus. In addition, diagnosis, symptom management and emerging therapies are addressed.

    • Liza K. Phillips
    • , Adam M. Deane
    • , Karen L. Jones
    • , Chris K. Rayner
    •  & Michael Horowitz
  • Reviews |

    Gastroparesis is a prevalent condition that produces symptoms of delayed gastric emptying in the absence of physical blockage. Over the past 5 years, considerable advances have been made in understanding gastroparesis, and the number of treatment options has expanded. William Hasler thus provides a timely Review of the pathogenesis, diagnosis and management of this condition.

    • William L. Hasler

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