Gastrointestinal hormones articles from across Nature Portfolio

A metagenomic analysis reveals that male and female mice exhibit sex-dependent responses to a high-fat diet (HFD), and that estrogenic ligands can attenuate certain aspects of HFDinduced dysbiosis.

Malita, Kubrak et al. show that the gut-derived hormone neuropeptide F suppresses sugar intake and increases the consumption of protein-rich food in Drosophila. This gives insight into the regulation of nutrient-specific appetite that ensures appropriate food choices to meet nutritional demands.

Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating GLP-1 levels through suppression of hepatic CYP8B1 expression and bile acid mediated inhibition of intestinal FXR signalling.