Functional magnetic resonance imaging articles from across Nature Portfolio

Bueichekú et al. use multimodal in vivo neuroimaging to investigate the brain characteristics of individuals presenting unawareness of memory loss who are at risk of Alzheimer’s disease due to age. They find unawareness of memory decline is an early behavioral sign that a person might develop Alzheimer’s disease.

The relationship between striatal vascular and neural activity is not fully understood. Here the authors found neuronal activity inadequately explains striatal hemodynamic polarity, challenging classic fMRI interpretations.

A longitudinal aging study using fMRI in anesthetized mice suggests brain network changes like humans. Mostly, female mice show a de-differentiation of networks with increased connectivity of prefrontal to somatomotor and somatosensory networks.

By integrating neuroimaging and multi-omics data, we established links between individual genetic variations and macro- to microscale brain circuit dysfunctions, specifically in corticocortical and corticostriatal circuits, that contribute to the diverse clinical manifestations of schizophrenia. These findings advance our understanding of the disease’s heterogeneity and offer potential treatment insights.

Core features of the language network in the brain are consistent across languages and language families.