Functional gastrointestinal disorders articles from across Nature Portfolio

Functional gastrointestinal disorders are a range of disorders of the gastrointestinal tract for which there are no structural or biochemical abnormalities that can be found to explain the symptoms. Examples include irritable bowel syndrome and functional dyspepsia.

Latest Research and Reviews

Research
09 February 2023 | Open Access

The effect of puppyhood and adolescent diet on the incidence of chronic enteropathy in dogs later in life
- Kristiina A. Vuori
- , Manal Hemida
- & Anna Hielm-Björkman
Scientific Reports 13, 1830
Reviews | 27 September 2022

Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome

There are limited available treatment options for the management of abdominal pain in irritable bowel syndrome (IBS). This Review provides an overview of the gastrointestinal endocannabinoid system and its potential as a therapeutic target for the treatment of pain in IBS.
- Stuart M. Brierley
- , Beverley Greenwood-Van Meerveld
- & Jan Tack
Nature Reviews Gastroenterology & Hepatology 20, 5-25
Research
03 September 2022 | Open Access

Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Host defense against helminth infection is mediated by mucosal type 2 immunity. Using gain- and loss-of-function mouse models, and mouse intestinal organoids, Xiong et al. show that SIRT6 modulates tuft and goblet cell expansion in intestinal epithelium by activating STAT6 to maintain type 2 mucosal immunity in response to helminth infection.
- Xiwen Xiong
- , Chenyan Yang
- & Qingzhi Wang
Nature Communications 13, 5192
Reviews | 10 August 2022

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

Genetic predisposition contributes to disease pathophysiology in irritable bowel syndrome (IBS). This Review provides a comprehensive overview of genetic research in IBS and discusses new concepts in IBS genetics.
- Michael Camilleri
- , Alexandra Zhernakova
- & Mauro D’Amato
Nature Reviews Gastroenterology & Hepatology 19, 689-702
Reviews | 10 August 2022

Faecal incontinence in adults

Faecal incontinence is defined by the unintentional loss of solid or liquid stool and can markedly impair quality of life. This Primer summarizes the epidemiology, pathophysiology and diagnosis of faecal incontinence in adults as well as its management, patient quality of life and areas for future research.
- Adil E. Bharucha
- , Charles H. Knowles
- & Paul Enck
Nature Reviews Disease Primers 8, 53
Research
14 July 2022 | Open Access

Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation
- Lijun Liu
- , Natalija Milkova
- & Ji-Hong Chen
Scientific Reports 12, 12051

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News and Comment

News & Views | 29 November 2022

Targeting the gut microenvironment in IBS to improve symptoms

Key studies published in 2022 further established the importance of alterations in the gut microenvironment and interactions with the enteric and central nervous systems in symptom generation in irritable bowel syndrome and suggested novel and clinically accessible therapeutic approaches for this large group of patients.
- Magnus Simrén
Nature Reviews Gastroenterology & Hepatology 20, 69-70
Research Highlights | 18 August 2022

Bacterial histamine and abdominal pain in IBS
- Katrina Ray
Nature Reviews Gastroenterology & Hepatology 19, 623
Research Highlights | 06 May 2022

Regulating protease homeostasis in irritable bowel syndrome
- Katrina Ray
Nature Reviews Gastroenterology & Hepatology 19, 415
Research Highlights | 10 March 2022

Abdominal pain in irritable bowel syndrome
- Nathalie Vergnolle
Nature Reviews Gastroenterology & Hepatology 19, 350
Editorial | 27 September 2021

Break the taboo with poo

We need to talk about poo. Everybody does it, and research into defaecation and associated disorders deserves more attention.

Nature Reviews Gastroenterology & Hepatology 18, 743
Comments & Opinion | 10 May 2021

Digital biomarkers in human excreta

Traditionally underutilized human excreta have emerged as a rich source of digital biomarkers for disease prevention and early detection. In this Comment, we highlight the breadth of digital biomarkers that can be extracted from human excreta and their potential uses in the context of ‘precision health’.
- Seung-min Park
- , T. Jessie Ge
- & Joseph C. Liao
Nature Reviews Gastroenterology & Hepatology 18, 521-522

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Functional gastrointestinal disorders articles from across Nature Portfolio

Latest Research and Reviews

The effect of puppyhood and adolescent diet on the incidence of chronic enteropathy in dogs later in life

Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome

Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

Faecal incontinence in adults

Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation

News and Comment

Targeting the gut microenvironment in IBS to improve symptoms

Bacterial histamine and abdominal pain in IBS

Regulating protease homeostasis in irritable bowel syndrome

Abdominal pain in irritable bowel syndrome

Break the taboo with poo

Digital biomarkers in human excreta

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Functional gastrointestinal disorders articles from across Nature Portfolio

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Latest Research and Reviews

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