Functional clustering articles within Nature

Featured

• Article | 27 February 2019

  Colonic epithelial cell diversity in health and inflammatory bowel disease

  Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.

  • Kaushal Parikh
  • , Agne Antanaviciute
  •  & Alison Simmons

• Letter | 29 October 2018

  Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

  An integrated RNA-sequencing approach demonstrates that CXCL13⁺ T_H1-like cells are preferentially enriched in microsatellite-instable tumours from patients with colorectal cancer, and IGFLR1 is identified as a co-stimulatory molecule.

  • Lei Zhang
  • , Xin Yu
  •  & Zemin Zhang

• Letter | 14 March 2018

  A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

  WebAnalysis of gene expression at single-cell resolution in the developing prefrontal cortex of the human embryo reveals a diversity of cell types, elucidates cell lineages and identifies signalling pathways that regulate development.

  • Suijuan Zhong
  • , Shu Zhang
  •  & Xiaoqun Wang

• Article | 30 August 2017

  Commensal bacteria make GPCR ligands that mimic human signalling molecules

  Commensal bacteria have N-acyl amide synthase genes that encode signalling molecules (N-acyl amides) that can interact with G-protein-coupled receptors and elicit host cellular responses similar to eukaryotic N-acyl amides.

  • Louis J. Cohen
  • , Daria Esterhazy
  •  & Sean F. Brady

• Letter | 29 September 2016

  Single-cell RNA-seq identifies a PD-1^hi ILC progenitor and defines its development pathway

  Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs can also be depleted by a PD-1 antibody.

  • Yong Yu
  • , Jason C. H. Tsang
  •  & Pentao Liu