Forgetting

  • Article
    | Open Access

    Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.

    • Chiara Mariottini
    • , Leonardo Munari
    •  & Ravi Iyengar
  • Article
    | Open Access

    Emotional memory can change when retrieved, yet the conditions under which this can occur are not fully described. Here, authors show that taking a pill of propranolol taken during a specific time window can change the expression of fear memory in a person, and that sleep is necessary to forget learned fear.

    • Merel Kindt
    •  & Marieke Soeter
  • Article
    | Open Access

    New neurons are continuously produced throughout adulthood in the hippocampus. Here the authors provide evidence that adult hippocampal neurogenesis weakens existing memories, and facilitates the encoding of new, confliction information in mice.

    • Jonathan R. Epp
    • , Rudy Silva Mera
    •  & Paul W. Frankland
  • Article
    | Open Access

    Rapidly switching the focus of attention is believed to impair memory, but it is unclear how. Lewis-Peacock and Norman use brain imaging and multivariate analysis to show that when two memories briefly and closely compete in the brain, there is a lasting impairment in the ability to remember these thoughts.

    • Jarrod A. Lewis-Peacock
    •  & Kenneth A. Norman