Follicular dendritic cells (FDCs) in lymph nodes support the development of high-affinity antibody responses by retaining antigens at their cell surface for long periods of time. Although FDCs are generally regarded as 'accessory cells' in the germinal centre, recent data suggest that they have more active roles in the development of humoral immune responses. This Review focuses on our current understanding of FDCs.
- Balthasar A. Heesters
- Riley C. Myers
- Michael C. Carroll
