Fat metabolism

Fat metabolism refers to the processes involved in the biosynthesis and breakdown of fats.

Featured

Latest Research and Reviews

News and Comment

  • News and Views |

    Aberrant upregulation of de novo lipogenesis is linked to non-alcoholic fatty liver disease and some cancers. A new study by Kelly et al. finds that inhibiting this pathway by blocking the activity of acetyl-CoA carboxylase has unexpected effects on the formation of platelets from megakaryocytes within the bone marrow of primates but not rodents, thus suggesting clinical implications for de novo lipogenesis inhibitors as a new class of therapeutics.

    • Ishac Nazy
    • , Donald M. Arnold
    •  & Gregory R. Steinberg
  • News and Views |

    Thermogenic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes mellitus. However, hurdles exist in activating thermogenic adipose tissue in humans. A new study developed a drug screening platform utilizing human beige adipose tissue and identified non-canonical activators.

    • Anthony R. P. Verkerke
    •  & Shingo Kajimura
  • News and Views |

    Lifespan is increased and ageing is delayed by lifelong dietary restriction. A study in Nature Metabolism shows that these benefits are reduced when dietary restriction is started in old age, owing to the development of an inflexible nutritional memory within white adipose tissue.

    • Stephen J. Simpson
    •  & David G. Le Couteur
    Nature Metabolism 1, 1030-1031
  • News and Views |

    Systemic accumulation of branched-chain amino acids (BCAAs) is a major metabolic hallmark and contributor to insulin resistance associated with obesity. A recent report identifies SLC25A44 as the BCAA transporter in mitochondrial membranes and shows that BCAA catabolism in brown adipose tissue significantly affects thermogenic activity, systemic BCAA clearance, energy expenditure and overall metabolic health.

    • Haipeng Sun
    •  & Yibin Wang
    Nature Metabolism 1, 845-846