Fanconi syndrome articles from across Nature Portfolio

Patients with haematological cancer are at risk of kidney injury, whether as a direct consequence of the malignancy or because of treatment-related effects. Here, the authors review the most common causes of kidney injury in these patients and discuss their pathophysiology, presentation and management.

Monoclonal immunoglobulin deposition produces complex diseases with heterogeneous phenotypes, making it difficult to identify the underlying mechanisms of immunoglobulin aggregation and deposition. In this Review, the authors discuss animal models of various human immunoglobulin deposition diseases, and each model's drawbacks and contributions to our understanding of these diseases.

Nephropathic cystinosis is a lysosomal storage disease characterized by proximal tubular cell dysfunction. Here Festa and colleagues show that these lysosomal alterations lead to defective autophagic clearance of mitochondria and increased oxidative stress that, in turn, activates the transcription factor ZONAB leading to impaired cell differentiation.

Reactive aldehydes generated by metabolism may contribute to the pathogenesis of Fanconi anaemia.