Extracellular recording

Extracellular recording is an electrophysiology technique that uses an electrode inserted into living tissue to measure electrical activity coming from adjacent cells, usually neurons.

Latest Research and Reviews

Research
26 December 2022 | Open Access

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex

Neuronal organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes and two photon imaging for longitudinal, multimodal monitoring of functional connectivity between human iPSC derived neuronal organoids and the mouse cortex.
- Madison N. Wilson
- , Martin Thunemann
- & Duygu Kuzum
Nature Communications 13, 7945
Research | 03 October 2022

Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents

Optimized ultraflexible electrode arrays enable months-long electrophysiological recordings of several thousand neurons at densities of up to 1,000 neural units per cubic millimetre.
- Zhengtuo Zhao
- , Hanlin Zhu
- & Chong Xie
Nature Biomedical Engineering, 1-13
Research
21 September 2022 | Open Access

Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice

Technologies for monitoring electrophysiological effects of drugs in behaving animals have limitations. Here the authors report a wireless neural probe system with drug delivery capability for real-time monitoring of drug effects.
- Yousang Yoon
- , Hyogeun Shin
- & Il-Joo Cho
Nature Communications 13, 5521
Research
29 July 2022 | Open Access

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo.
- Tal Sharf
- , Tjitse van der Molen
- & Kenneth S. Kosik
Nature Communications 13, 4403
Research
14 June 2022 | Open Access

Riemannian geometry-based transfer learning for reducing training time in c-VEP BCIs
- Jiahui Ying
- , Qingguo Wei
- & Xichen Zhou
Scientific Reports 12, 9818
Research
30 March 2022 | Open Access

Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks
- Fikret Emre Kapucu
- , Andrey Vinogradov
- & Susanna Narkilahti
Scientific Data 9, 120

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News and Comment

Comments & Opinion | 03 March 2022

Openness about animal research increases public support

Science engagement can be a daunting prospect. This is especially true for scientists whose work involves animal models, and particularly nonhuman primates. Here, we show that openly explaining our rationale for our neuroscience work involving nonhuman primates — and the legal and ethical regulations that govern animal experimentation — increased public support and understanding, which is crucial for this essential research to continue.
- Juan Carlos Mendez
- , Brook A. L. Perry
- & Anna S. Mitchell
Nature Neuroscience 25, 401-403
Research Highlights | 06 January 2022

Localizing spikes
- Sachin Ranade
Nature Neuroscience 25, 2
Research Highlights | 02 July 2020

Benchmarked spike sorting
- Nina Vogt
Nature Methods 17, 656
Research Highlights | 30 January 2019

Large-scale electrophysiology with polymer-based electrodes
- Nina Vogt
Nature Methods 16, 143
Research Highlights | 11 December 2017

A miniature living recording device
- Liesbet Lieben
Nature Reviews Genetics 19, 65
Research Highlights | 01 December 2015

In silico neocortex

Nature Methods 12, 1115

All News & Comment

Extracellular recording

Latest Research and Reviews

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex

Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents

Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Riemannian geometry-based transfer learning for reducing training time in c-VEP BCIs

Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks

News and Comment

Openness about animal research increases public support

Localizing spikes

Benchmarked spike sorting

Large-scale electrophysiology with polymer-based electrodes

A miniature living recording device

In silico neocortex

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