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Article
| Open Access
Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping
The invasiveness of extensive craniotomy hinders large-scale cortex mapping. Here, the authors developed a flexible, shape-changing electrode array which enables minimally invasive implantation and achieves high spatiotemporal resolution brain mapping.
- Shiyuan Wei
- , Anqi Jiang
- & Xiaojie Duan
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Article
| Open Access
Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
Neuronal organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes and two photon imaging for longitudinal, multimodal monitoring of functional connectivity between human iPSC derived neuronal organoids and the mouse cortex.
- Madison N. Wilson
- , Martin Thunemann
- & Duygu Kuzum
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Article
| Open Access
Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice
Technologies for monitoring electrophysiological effects of drugs in behaving animals have limitations. Here the authors report a wireless neural probe system with drug delivery capability for real-time monitoring of drug effects.
- Yousang Yoon
- , Hyogeun Shin
- & Il-Joo Cho
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Article
| Open Access
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo.
- Tal Sharf
- , Tjitse van der Molen
- & Kenneth S. Kosik
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Article
| Open Access
Enabling comprehensive optogenetic studies of mouse hearts by simultaneous opto-electrical panoramic mapping and stimulation
Current cardiac mapping systems provide either electrical or optical readouts. Here the authors report a panoramic opto-electrical measurement and stimulation (POEMS) system which embraces the entire ventricular surface of mouse hearts, allowing flexible combinations of optical and electrical recording and stimulation modalities.
- Michael Rieger
- , Christian Dellenbach
- & Stephan Rohr
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Article
| Open Access
Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes
Silicon probes for electrical recording from neurons usually have fewer wires than recording channels available to carry signals off the probe, which restricts the number of channels that can be recorded simultaneously. The authors propose to pool electrodes, using a single wire to serve many channels through a set of controllable switches.
- Kyu Hyun Lee
- , Yu-Li Ni
- & Markus Meister
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Article
| Open Access
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
Currently technologies for monitoring and controlling neural activities in 3D models are lacking. Here the authors report a 3D high-density multielectrode array, with optical stimulation and drug delivery, to investigate neural circuit dynamics in engineered 3D neural tissues.
- Hyogeun Shin
- , Sohyeon Jeong
- & Il-Joo Cho
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Article
| Open Access
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
Current methods of neuronal network imaging cannot be used for continuous, long-term functional recordings. Here, the authors present a dual-mode high-density microelectrode array, which can simultaneously record in full-frame and high-signal-to-noise modes for label-free electrophysiological measurements.
- Xinyue Yuan
- , Manuel Schröter
- & Urs Frey
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Article
| Open Access
The mediodorsal pulvinar coordinates the macaque fronto-parietal network during rhythmic spatial attention
Recent evidence shows that spatial attention is discontinuous over time, sampling locations in rhythmic cycles (3–6 Hz). Here, the authors show that the pulvinar has a role in coordinating this rhythmic sampling, with neural activity propagating from pulvinar to cortex during periods of engagement.
- Ian C. Fiebelkorn
- , Mark A. Pinsk
- & Sabine Kastner
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Article
| Open Access
Changing temporal context in human temporal lobe promotes memory of distinct episodes
Memories formed around the same time are linked together by a shared temporal context. Here, the authors show that the ability to selectively retrieve distinct episodic memories formed close together in time is related to how quickly neural representations of temporal context change over time during encoding.
- Mostafa M. El-Kalliny
- , John H. Wittig Jr
- & Kareem A. Zaghloul
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Article
| Open Access
A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers
Peripheral nerves have a complex physiology and it is therefore difficult to measure axonal activity in vitro. Here the authors make a nerve-on-a-chip platform to align peripheral nerves and permit measurement of conduction amplitude and velocity along several axons in a single experiment.
- Sandra Gribi
- , Sophie du Bois de Dunilac
- & Stéphanie P. Lacour
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Article
| Open Access
Oscillatory brain activity in spontaneous and induced sleep stages in flies
Sleep in mammals comprises physiologically and functionally distinct stages. Here, the authors report a transitional sleep stage in Drosophila associated with 7–10 Hz oscillatory activity that can be obtained through activation of the sleep-promoting neurons of the dorsal fan-shaped body.
- Melvyn H. W. Yap
- , Martyna J. Grabowska
- & Bruno van Swinderen
T-DOpE probes reveal sensitivity of hippocampal oscillations to cannabinoids in behaving mice